September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Enhanced Depth Image Optical Coherence Tomography (EDI-OCT) choroidal evaluation in patients with diabetes and correlation with retinal and kidney disease
Author Affiliations & Notes
  • Maria Fernanda Abalem
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Rony Carlos Preti
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Rafael Garcia
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Helen Nazareth Veloso Santos
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Pedro C Carricondo
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Sérgio Luís Gianotti Pimentel
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Walter Y Takahashi
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Mario L R Monteiro
    Ophthalmology, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships   Maria Fernanda Abalem, None; Rony Preti, None; Rafael Garcia, None; Helen Santos, None; Pedro Carricondo, None; Sérgio Pimentel, None; Walter Takahashi, None; Mario Monteiro, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6325. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Maria Fernanda Abalem, Rony Carlos Preti, Rafael Garcia, Helen Nazareth Veloso Santos, Pedro C Carricondo, Sérgio Luís Gianotti Pimentel, Walter Y Takahashi, Mario L R Monteiro; Enhanced Depth Image Optical Coherence Tomography (EDI-OCT) choroidal evaluation in patients with diabetes and correlation with retinal and kidney disease. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6325.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : This cross-sectional study aims to evaluate choroidal thickness in diabetic type 1 and 2 patients and assess the correlation between choroidal thickness and diabetic retinopathy (DR) and nephropathy (DN) staging.

Methods : 104 diabetic patients (203 eyes) were recruited from the Hospital das Clínicas of University of Sao Paulo’s ophthalmic patient population. Participants were excluded if they presented with refractive error > ±6.00 diopter (D,) spherical equivalent > 2 D of keratometric astigmatism or opacity of ocular media. Patients with history any retinal diseases other than DR, prior history of intraocular surgery, including intravitreal injections, in the past three months, or poor OCT image quality were also excluded.
All patients underwent ocular examination, including dilated fundus examination and EDI-OCT (Spectralis, Heidelberg Engineering, Germany). DR was classified into nonproliferative (NPDR), proliferative (PDR) and proliferative after panretinal photocoagulation (PPRP). Eyes without DR (WDR) were also considered.Choroidal thickness were addressed subfoveal, using a caliper available in the device software. The measures were obtained perpendicularly, from the outer edge of hyperreflective retinal pigment epithelium to the inner sclera.Two raters experienced in examining EDI-OCT images independently evaluated choroidal thickness. A third rater was consulted when the two raters disagreed.
Renal evaluation: blood samples were collected for creatinine analysis and used for nephropathy classification into normal, mild, moderate and severe, based on MDRD study group.

Results : The mean age was 59,3 years (range, 18-78) and 50% were women.
The mean choroidal thickness was 301,31 µm, 240 µm and 272,81 µm in the NPDR, PPRP and WDR groups, respectively, with statically significant difference between NPDR and PPRP groups (P=0.011). Choroidal thickness in patients without DR was similar to NPRD and PPRP patients (P=0,277). Regarding DN, choroidal thickness was not different among groups (P=0,173). No patients with PDR were included.

Conclusions : Our data suggest that in patients with NPDR and PPRP there is a decrease of choroidal thickness, that was not observed in patients without DR. Studies with a higher number of subjects with DR could first, elucidate the role of VEGF in choroid and second, to confirm our findings.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×