September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Morphological and Functional Evaluation Of Diabetic Eyes Without Diabetic Retinopathy
Author Affiliations & Notes
  • Ilaria Zucchiatti
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Giuseppe Querques
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Giuseppe Casalino
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Federico Corvi
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Maria Lucia Cascavilla
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Enrico Borrelli
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Lucia Benatti
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Livia Tomasso
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Adriano Carnevali
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
    Department of Ophthalmology, University Magna Graecia, Catanzaro, Italy
  • Francesco Bandello
    Department of Ophthalmology, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy
  • Footnotes
    Commercial Relationships   Ilaria Zucchiatti, None; Giuseppe Querques, Alimera sciences (C), Allergan (C), Bausch and Lomb (C), Bayer schering pharma (C), Heidelberg (C), Novartis (C), Zeiss (C); Giuseppe Casalino, None; Federico Corvi, None; Maria Lucia Cascavilla, None; Enrico Borrelli, None; Lucia Benatti, None; Livia Tomasso, None; Adriano Carnevali, None; Francesco Bandello, ALCON (C), ALIMERA SCIENCE (C), ALLERGAN (C), BAUSCH&LOMB (C), BAYER (C), FARMILA THEA (C), GENENTECH (C), HOFMANN LA ROCHE (C), NOVAGALI PHARMA (C), NOVARTIS (C), SANOFI AVENTIS (C), THROMBOGENICS (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6350. doi:
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      Ilaria Zucchiatti, Giuseppe Querques, Giuseppe Casalino, Federico Corvi, Maria Lucia Cascavilla, Enrico Borrelli, Lucia Benatti, Livia Tomasso, Adriano Carnevali, Francesco Bandello; Morphological and Functional Evaluation Of Diabetic Eyes Without Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6350.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess early morpho-functional changes that precede clinical signs of diabetic retinopathy (DR) in type 2 diabetic patients with no signs of DR

Methods : Twelve consecutive type 2 diabetic patients without DR and 12 healthy controls of similar age underwent a comprehensive ophthalmologic examination, including spectral-domain optical coherence tomography (SD-OCT), microperimetry (MP-1 microperimeter Nidek Technologies, Padova, Italy) and multifocal electroretinography (mfERG, RE-TI scan multifocal system, Roland Consult, Brandenburg, Germany). Microperimetry assessed retinal sensitivity map with customized grid of 45 Goldmann III stimuli covering the central 12° microperimetry. mfERG analyzed the first-order mfERG responses, namely the P1 and N1 amplitudes

Results : Twenty-four eyes of type 2 diabetic patients (7 males, 5 females, mean age of 61.8 ± 5.7) and 24 eyes of 12 healthy controls (8 males, 4 females, mean age of 62.7 ± 5.1) were included in this study. Mean central foveal thickness (CFT) was 245.4 ±29 µm and 224.5 ±12 µm, in diabetic eyes and healthy controls, respectively (p=0.007). Mean retinal sensitivity on microperimetry was 17.98 ±1.58 dB and 19 ±0.46 dB, in diabetics and controls, respectively (p=0.01). mfERG showed normal amplitude of waves N1-P1 with a normal implicit time in both groups: the mean amplitude of N1 in the three central rings was -0.54 ± 0.41, -0.29 ± 0.20, -0.25 ± 0.10 and -0.53 ± 0.1, -0.28 ± 0.06, -0.23 ± 0.06 in diabetic eyes and healthy controls, respectively (p=0.2, p=0.6, p=0.5); the mean amplitude of P1 in the three central rings was 0.70 ± 0.31, 0.43 ± 0.24, 0.28 ± 0.15 and 0.75 ± 0.19, 0.39 ± 0.08, 0.26 ± 0.06 in diabetic eyes and healthy controls, respectively (p=0.4, p=0.5, p=0.8)

Conclusions : Compared to healthy controls, type 2 diabetic patients without DR present significantly thickened CFT on SD-OCT and reduced sensitivity on microperimetry, but similar mfERG findings

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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