September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Five-year Outcomes of Inner Segment Ellipsoid and External Limiting Membrane Status after Pars Plana Vitrectomy in Diabetic Macular Edema
Author Affiliations & Notes
  • Shogo Yamamoto
    Kobe City Medical Center General Hospital, Kobe, Japan
    Institute of Biomedical Research and Innovation, Kobe, Japan., Kobe, Japan
  • Noriko Miyamoto
    Kobe City Medical Center General Hospital, Kobe, Japan
    Institute of Biomedical Research and Innovation, Kobe, Japan., Kobe, Japan
  • Masashi Fujihara
    Kobe City Medical Center General Hospital, Kobe, Japan
    Institute of Biomedical Research and Innovation, Kobe, Japan., Kobe, Japan
  • Kazuhiro Ishida
    Kobe City Medical Center General Hospital, Kobe, Japan
    Institute of Biomedical Research and Innovation, Kobe, Japan., Kobe, Japan
  • Yasuo Kurimoto
    Kobe City Medical Center General Hospital, Kobe, Japan
    Institute of Biomedical Research and Innovation, Kobe, Japan., Kobe, Japan
  • Footnotes
    Commercial Relationships   Shogo Yamamoto, None; Noriko Miyamoto, None; Masashi Fujihara, None; Kazuhiro Ishida, None; Yasuo Kurimoto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6361. doi:
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      Shogo Yamamoto, Noriko Miyamoto, Masashi Fujihara, Kazuhiro Ishida, Yasuo Kurimoto; Five-year Outcomes of Inner Segment Ellipsoid and External Limiting Membrane Status after Pars Plana Vitrectomy in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6361.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : It has been reported that the preserved inner segment ellipsoid (ISe) and external limiting membrane (ELM) are associated with maintaining visual acuity (VA) in diabetic macular edema (DME) patients. We reported previously that ISe and ELM status once deteriorated after pars plana vitrectomy (PPV), then ELM did not recovered, while IS/OS status recovered and visual acuity (VA) improved after that up to1 year (2013 ARVO). Then we studied the ISe and ELM status of optical coherence tomography (OCT) images in DME for a long period.

Methods : We retrospectively reviewed the spectral-domain OCT images of 21 eyes from 18 cases with DME who were treated with PPV and evaluated various factors such as the status of ELM and ISe, central retinal thickness (CRT) and VA up to 5 years (Y). We used a percentage disruption to evaluate the status of ELM and ISe.

Results : logMAR VA was 0.419 at pre-PPV and improved to 0. 242 at 3Y(P<0.001), then to 0.224 at 5Y (P<0.001) after PPV. CRT was 481.8 μm at pre-PPV, decreased to 326 μm at 3Y (P<0.001), then 276.6 μm at 5Y(P<0.001) after PPV. The percentage disruption of ISe was 28.1 % at pre-PPV and decreased gradually to 12.5% at 3Y (P=0.01), then 13.9% at 5Y after PPV (P=0.035). The percentage disruption of ELM was 11.4% at pre-PPV, and decreased to to 8.8% at 3Y (P=0.97), 6.2% at 5Y after PPV (P=0.65).

Conclusions : VA and ISe improved and CRT decreased significantly at 3Y after PPV, then improved VA and ISe and decreased CRT were maintained up to 5Y.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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