September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes
Author Affiliations & Notes
  • Nicolas Alessandro Yannuzzi
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Ajay E. Kuriyan
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Jayanth Sridhar
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Harry W Flynn
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Laura Huang
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • William E Smiddy
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Janet L Davis
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Thomas Arno Albini
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Audina M Berrocal
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Darlene Miller
    Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Nicolas Yannuzzi, None; Ajay Kuriyan, None; Jayanth Sridhar, None; Harry Flynn, None; Laura Huang, None; William Smiddy, None; Janet Davis, None; Thomas Albini, None; Audina Berrocal, None; Darlene Miller, None
  • Footnotes
    Support  This study is supported in part by NIH Center Core Grant P30EY014801, Research to Prevent Blindness Unrestricted Grant, Department of Defense (DOD- Grant#W81XWH-09-1-0675).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6385. doi:
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      Nicolas Alessandro Yannuzzi, Ajay E. Kuriyan, Jayanth Sridhar, Harry W Flynn, Laura Huang, William E Smiddy, Janet L Davis, Thomas Arno Albini, Audina M Berrocal, Darlene Miller; Endophthalmitis Caused by Corynebacterium Species: Clinical Features, Antibiotic Susceptibility, and Treatment Outcomes
      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):6385.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report the clinical features, antibiotic susceptibility profiles, treatment, and visual acuity (VA) outcomes of endophthalmitis caused by Corynebacterium species.

Methods : A consecutive case series of patients with culture-positive endophthalmitis caused by Corynebacterium species between January 1, 1990 and December 31, 2012 at an academic referral center.

Results : Of 10 patients identified, clinical settings included post-cataract surgery (n = 6), post-penetrating keratoplasty (n = 2), and post-trabeculectomy (n = 2). The mean time from surgical procedure to presentation with endophthalmitis was 6.8 months (range: 1 day to 28 months). All isolates were vancomycin susceptible. Presenting VA ranged from 7/200 to no light perception. Initial treatment strategies were vitreous tap and intravitreal antibiotic injection (n = 5) and pars plana vitrectomy with intravitreal antibiotic injection (n = 5). VA outcomes were ≥ 20/60 in 5 (50%) of 10 patients and ≤ 20/400 in 5 (50%) of 10 patients.

Conclusions : The most common clinical setting was post-cataract surgery. All isolates were susceptible to vancomycin. Despite prompt treatment with appropriate antibiotics, there were variable visual outcomes.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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