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Shenouda Yacoub, Byron H Li, Muneto Mogi, Dennis S Rice, Ganesh Prasanna; Effects of Nitric Oxide Donors on Intraocular Pressure in Cynomolgus Monkeys. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6410.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the effects of various nitric oxide (NO) donors on intraocular pressure (IOP) in experimental glaucomatous monkey eyes following topical ocular dosing.
Chronic ocular hypertension (OHT) was induced in the right eye of cynomolgus monkeys by argon laser trabecular photocoagulation. The effect of various NO donors on IOP was evaluated in conscious animals using a computerized applanation pneumatonometer.
Average baseline IOP in the hypertensive monkey eyes was between 34 - 40 mmHg compared to the 24 – 30 mmHg in the contralateral normotensive eye. A molsidomine derivative: SIN-1 (dosed at 300 mg) caused IOP lowering of 19 ± 3% at 3 hours and 18 ± 4% at 6 hours post-dose in the hypertensive eye. In normotensive monkey eyes, SIN-1 was not efficacious. Isosorbide 5-mononitrate, an isosorbide caused IOP reduction of 14 ± 4% at 1 hour post-dose but was not efficacious at 6 hours post-dose in the hypertensive monkey eye. A dinitroglycerine derivative 1 ,3 Dinitroglycerin (dosed at 50 mg and 500 mg) caused an acute IOP reduction of 14% at 1 hour post-dose for both doses and was minimally efficacious at 6 hours (<8%) for both doses in the hypertensive monkey eye.
NO donors lower IOP in the hypertensive eyes of a monkey model of glaucoma. Among the several classes of NO donors tested, SIN-1 appeared to cause the most robust IOP reduction in the monkey model of glaucoma compared to Isosorbide 5-mononitrate and 1,3-Dinitroglycerin. Additional classes of NO donors are being evaluated for their effects on IOP in this model of glaucoma.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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