September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Comparison of 24-Hour IOP Measurements in Sitting and Supine Positions in Glaucoma
Author Affiliations & Notes
  • Erica A Borges
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Sebastiao Cronemberger
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Nassim S Calixto
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Felipe A Medeiros
    Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Rafael Vidal Merula
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Maria Valeria C P Silva
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Alberto Diniz-Filho
    Glaucoma Division, Hospital Sao Geraldo, Department of Ophthalmology and Otorhinolaryngology, Federal Universilty of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Erica Borges, None; Sebastiao Cronemberger, None; Nassim Calixto, None; Felipe Medeiros, Alcon Laboratories (R), Alcon Laboratories (F), Allergan (F), Allergan (R), Allergan (C), Bausch & Lomb (F), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Carl Zeiss Meditec (C), Heidelberg Engineering (F), Merck (F), National Eye Institute (F), Novartis (C), Reichert (R), Reichert (F), Sensimed (F), Topcon (F); Rafael Merula, None; Maria Valeria Silva, None; Alberto Diniz-Filho, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6434. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Erica A Borges, Sebastiao Cronemberger, Nassim S Calixto, Felipe A Medeiros, Rafael Vidal Merula, Maria Valeria C P Silva, Alberto Diniz-Filho; Comparison of 24-Hour IOP Measurements in Sitting and Supine Positions in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6434.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To assess correlation and agreement between sitting and supine intraocular pressure (IOP) measurements in glaucoma patients and suspects as part of 24-hour IOP curve.

Methods : Measurements were performed in the sitting position using a Goldmann tonometer and in the supine position using a Perkins tonometer. IOP measurements were obtained at 7 am in the sitting position once patients arrived at the office. Patients were asked to lie down in the supine position and IOP was measured in a dark room right after at 8 am. After 60 minutes in the same conditions, IOP measurements were obtained at 9 am. After remaining hospitalized during the night, the IOP was measured in the next day upon awaking in the supine position before getting out of the bed in a dark room. The IOP measurements at 6 am, 7 am, 8 am, and 9 am were compared using a paired t-test and peak was determined when IOP>21 mmHg. Agreement between the measurements was assessed using Bland-Altman plots. Generalized estimating equations models were used to investigate the relationship between IOP measurements, taking into account the correlation between fellow eyes.

Results : The study included 138 eyes of 72 glaucoma patients and suspects. Mean age was 65.6 ± 14.4 years. Mean IOP was 16.0 ± 5.2 mmHg at 6 am, 14.0 ± 3.6 mmHg at 7 am, 14.5 ± 4.2 mmHg at 8 am, and 14.1 ± 4.2 mmHg at 9 am. IOP measurements at 6 am upon awaking in the supine position were associated with the IOP measurements at 9 am after 60 minutes in the supine position (R2=48.6%; P<0.001), 8 am in the supine position (R2=41.3%; P<0.001), and 7 am in the sitting position (R2=31.9%; P<0.001). This association was expected since measurements were closer in time. Mean differences between measurements at 6 am and those at 7 am, 8 am, and 9 am were respectively 1.9 (95% CI 1.2 to 2.7), 1.5 (95% CI 0.8 to 2.2), and 1.9 (95% CI 1.2 to 2.5) mmHg. Twenty eyes (14.5%) had peak (IOP>21 mmHg) at 6 am. Eight eyes (5.8%) had peak at 8 am and only 5 eyes (3.6%) had peak at 7 am and 9 am.

Conclusions : Despite the association, agreement among IOP measurements taken at 6 am in the supine position upon awaking in a dark room and the others measurements in the supine position was poor. Further studies assessing also night IOP measurements are needed to better understand postural effect and circadian elevation of IOP.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×