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Pablo Sande, Agustina Iaquinandi, Javier Alvarez, Ruth E Rosenstein; Development of an experimental model of feline glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6451.
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© ARVO (1962-2015); The Authors (2016-present)
Glaucoma in cats represents a therapeutic challenge in veterinary ophthalmology. There are several shared characteristics in glaucoma among different species. However, many anti-glaucoma medications which are successfully used in humans and dogs, are not well tolerated by cats, and therefore, the selection drugs is limited in this species. An experimental model of glaucoma in cats would facilitate the development of new therapeutic strategies for thisfelinedisease. In this context, the aim of this work was to develop an experimental model of glaucoma in cats.
Fourmale spayed European shorthaired cats were subjected to diode laser (810 nm) photocoagulation of the trabecular meshwork in one eye, whereas the contralateral eye was subjected to a sham procedure. Ocular examination included Schirmer tear test measurements, fluorescein corneal staining, applanation tonometry (Tonopen Vet), biomicroscopy (slit lamp),pupil light reflex (PLR), and direct and indirect ophthalmoscopy.
Laser treatment induced a significant increase in intraocular pressure(IOP)at days 1, 3, 5, 7, 14, and 28 post-surgery, as compared with sham-treated eyes. At 3 days post-surgery, slight episcleralhyperemia,mydriasis and aqueous flarewere observed in laser-treated eyes. At 28 days post-surgery, no signs of inflammation were observed, mydriasis was more pronounced, and a significant decrease in PLR, and optic nerve cupping and atrophywere present in all laser-treated eyes.
These results indicate that laser photocoagulationof the trabecular meshwork mimics the central features of feline glaucoma. This experimental model could constitute a fertile avenue for the development of new therapeutic strategies in feline glaucoma treatment.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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