September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Continuous 24-hour monitoring of ocular dimensional changes using the Triggerfish Contact Lens Sensor in patients undergone canaloplasty surgery

Author Affiliations & Notes
  • Marek Rekas
    Ophthalmology, Military Institute of Medicine, WARSAW, Poland
  • Monika Ewa Danielewska
    Department of Biomedical Engineering, Wroclaw University of Technology, Wroclaw, Poland
  • Anna Byszewska
    Ophthalmology, Military Institute of Medicine, WARSAW, Poland
  • Joanna Wierzbowska
    Ophthalmology, Military Institute of Medicine, WARSAW, Poland
  • Katarzyna Petz
    Ophthalmology, Military Institute of Medicine, WARSAW, Poland
  • D Robert Iskander
    Department of Biomedical Engineering, Wroclaw University of Technology, Wroclaw, Poland
  • Footnotes
    Commercial Relationships   Marek Rekas, None; Monika Danielewska, None; Anna Byszewska, None; Joanna Wierzbowska, None; Katarzyna Petz, None; D Robert Iskander, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6460. doi:
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    • Get Citation

      Marek Rekas, Monika Ewa Danielewska, Anna Byszewska, Joanna Wierzbowska, Katarzyna Petz, D Robert Iskander; Continuous 24-hour monitoring of ocular dimensional changes using the Triggerfish Contact Lens Sensor in patients undergone canaloplasty surgery

      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):6460.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To ascertain whether 24-hour continuous monitoring of corneoscleral limbus area (CSLA) with the Triggerfish Contact Lens Sensor (TF-CLS) can be clinically utilized for assessing long-term efficacy of canaloplasty.

Methods : Ten patients with uncontrolled open angle glaucoma were recruited for the study. Patients underwent canaloplasty combined with cataract extraction. Eyes not previously operated were included with pre-op washout from antiglaucoma medications. Best corrected visual acuity (BCVA), intraocular pressure (IOP), anterior and posterior segments of the eye, number of medications were examined. Follow-up examinations were done on days 1 and 7 and at 1, 3, 6, and 12 months. Apart from standard clinical data, there were collected 10 pre-op records of 24-hour monitoring of changes at CSLA measured with TF-CLS, corresponding 10 records of 3 month post-op and 6 records of 12 month post-op monitoring. The TF-CLS gives 288 data packets (acquired every 5 minutes) of ocular volume changes taking 30 seconds each. Raw TF-CLS signals were numerically analysed to lead the best-sine wave fit for each of the daily records. Two parameters were considered: the amplitude of the fitted sine-wave and the overall root mean square (RMS) of the raw signal amplitude. Statistical analysis included standard descriptive statistics and paired t-test.

Results : Mean pre-operative IOP was 20.6 ±4.71 and was reduced to 14.2±3.03 (p<0.05) on 0.1±0.33 antiglaucoma medication, which equals to 31% IOP reduction. BCVA improved significantly. Diurnal changes in Triggerfish signal amplitude assumed to be equivalent to changes in ocular pulse amplitude. A post-op decrease in CSLA signal amplitudes was observed. Statistically significant differences between the pre-op and 3 month post-op for both the amplitude RMS and the sine-wave amplitude (paired t-test, p=0.022 and p=0.041, respectively) as well as between the pre-op and 12 month post-op results (p=0.043 and p=0.026, respectively) were found. No statistically significant differences were found between the 3 month post op and 12 month post-op results for both amplitude RMS and the sine-wave amplitude (p=0.296 and p=0.170, respectively).

Conclusions : A sine-wave pattern of continuous 24-hour CSLA signals can be used to monitor efficacy of canaloplasty.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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