September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Intraocular pressure affects structural glaucoma progression differently in patients of African and European descent
Author Affiliations & Notes
  • David Camp
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Nicholas Moore
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, IRCCS Policlinico San Matteo, Pavia, Italy
  • Jenny Wang
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • George Eckert
    Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aditya Belamkar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   David Camp, None; Alon Harris, AdOM (I), AdOM (C), Biolight (C), Isama Therapeutics (C), Nano Retina (C), Ono (C), Oxymap (I), Science Based Health (C), Stemnion Inc. (C); Nicholas Moore, None; Alice Chandra Verticchio Vercellin, None; Jenny Wang, None; George Eckert, None; Aditya Belamkar, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness NY, NY and NIH Grant 1R21EY022101-01A1
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6463. doi:
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      David Camp, Alon Harris, Nicholas Moore, Alice Chandra Verticchio Vercellin, Jenny Wang, George Eckert, Aditya Belamkar, Brent A Siesky; Intraocular pressure affects structural glaucoma progression differently in patients of African and European descent. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6463.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between intraocular pressure (IOP) and changes in structural progression in open-angle glaucoma (OAG) patients of African (AD) and European descent (ED) after four years

Methods : 85 patients with OAG (20 AD, 65 ED) were assessed for IOP and for optic nerve head (ONH) morphology and retinal nerve fiber layer (RNFL) thickness by Heidelberg retinal tomography 3 (HRT3) every six months for a four-year period. Additionally, 80 patients with OAG (18 AD, 62 ED) were assessed for IOP and for ONH parameters by optical coherence tomography (OCT) every six months over a four-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients assessed by HRT3, baseline IOP (mmHg) was 16.9 (95% CI: 14.9-18.8) and 15.6 (14.2-17.1) in patients of AD and ED, respectively. In OAG patients of AD, baseline IOP positively correlated with changes in rim volume (r=0.61, p=0.004), mean RNFL thickness (r=0.52, p=0.018), and RNFL cross-sectional area (r=0.49, p=0.027). Baseline IOP in patients of AD negatively correlated with changes in cup area (r=-0.47, p=0.036), cup/disc area ratio (r=-0.51, p=0.019), and linear cup/disc ratio (r=-0.48, p=0.031). In OAG patients of ED, these correlations were weak and non-significant (r=-0.16 to 0.16, all p>0.05); leading to a significant difference between groups (changes in rim volume: p=0.002, mean RNFL thickness: p=0.014, RNFL cross-sectional area: p=0.019, cup area: p=0.014, and cup/disc area ratio: p=0.009).
In OAG patients of AD assessed with OCT, change in IOP was positively correlated with changes in cup area (r=0.49, p=0.036), cup/disc area ratio (r=0.56, p=0.015), cup/disc horizontal ratio (r=0.63, p=0.004), and cup/disc vertical ratio (r=0.47, p=0.047), and negatively correlated with rim area (r=-0.51, p=0.030). In OAG patients of ED assessed with OCT, these correlations were weak and non-significant (r=-0.16 to 0.20, all p>0.05); leading to a significant difference between groups (p<0.05).

Conclusions : In this cohort of OAG patients, IOP was found to have a different influence on longitudinal structural progression in OAG patients of AD, compared to ED patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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