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Michael Gemayel, Bret A Hughes, Aman Shukairy, Mark Juzych, Anju Goyal, Chaesik Kim; Comparison of Outcome Following SLT in Primary Open-Angle Glaucoma and Normal Tension Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6481.
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Selective Laser Trabeculoplasty (SLT) has been demonstrated to be an effective treatment modality for both primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) patients. However, a comparison of outcomes following SLT between these patients has not been made. This is a retrospective clinical study designed to compare the efficacy of SLT in POAG and NTG patients.
This is a retrospective chart review of Kresge Eye Institute patients diagnosed with either POAG or NTG who underwent SLT between 2006 and 2015. Intraocular pressure and number of ocular medications were documented prior to SLT, at 1 month, 3, 6, 12, and 24 months post-SLT. Success was defined as ≥10% IOP reduction from baseline and IOP ≤21 mmHg without an increase in medication and no additional surgery. Kaplan-Meier survival plot was used for statistical analysis.
187 POAG eyes and 56 NTG eyes were included in the analysis. The mean age was 63.8 in the POAG group and 67.3 in the NTG group (p=0.01). The mean pre-IOP was 19.6 mmHg using 1.98 medications in the POAG group, and 14.8 mmHg using 1.18 medications in the NTG group (p<0.0001, p<0.0001, respectively). Kaplan-Meier survival analysis demonstrated a success rate of 42.9% in the POAG group, and 34.7% in the NTG group at 12 months. At 24 months, the success rate was 25.3% in the POAG group and 23.1% in the NTG group (Log-rank p=0.16). The mean percent reduction of IOP from pre-SLT values in the POAG group was 17% at 6 months (p=0.03), and 14.3% at 12 months (p=0.14), versus 8.5% at 6 months (p=0.03), and 4.7% at 12 months (p=0.14) in the NTG group.
Although the POAG group was younger and had a higher mean pre-IOP while using more ocular medications, SLT was an effective treatment modality for both POAG and NTG patients, with no statistically significant difference in success using our criteria.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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