October 2016
Volume 57, Issue 13
Open Access
Letters to the Editor  |   October 2016
Relationship of Goblet Cell Density and Glaucoma Filtration Surgery Outcome
Author Affiliations & Notes
  • Wenbin Huang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
  • Xiulan Zhang
    Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5405. doi:10.1167/iovs.16-20234
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    • Get Citation

      Wenbin Huang, Xiulan Zhang; Relationship of Goblet Cell Density and Glaucoma Filtration Surgery Outcome. Invest. Ophthalmol. Vis. Sci. 2016;57(13):5405. doi: 10.1167/iovs.16-20234.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
We congratulate Agnifili and colleagues1 for their study analyzing the relationship between goblet cell density and the outcome of glaucoma filtration surgery. They found that a higher preoperative goblet cell density was associated with a higher success rate. A previous study reported significant negative correlations between age and goblet cell density.2 However, our experience and the results of other studies showed that the success rate for glaucoma filtration surgery is higher in older than in younger patients.3 Thus, in addition to goblet cell density, other important factors appear to influence the surgery outcome. Further analysis (e.g., logistic regression) should be performed in their study to determine which of these factors is most relevant. 
References
Agnifili L, Fasanella V, Mastropasqua R, et al. In vivo goblet cell density as a potential indicator of glaucoma filtration surgery outcome. Invest Ophthalmol Vis Sci. 2016; 57: 2898–2905.
Wei A, Hong J, Sun X, Xu J. Evaluation of age-related changes in human palpebral conjunctiva and meibomian glands by in vivo confocal microscopy. Cornea. 2011; 30: 1007–1012.
Borisuth NS, Phillips B, Krupin T. The risk profile of glaucoma filtration surgery. Curr Opin Ophthalmol. 1999; 10: 112–116.
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