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Moritz Lindner, Petra P. Fang, Julia S. Steinberg, Niklas Domdei, Maximilian Pfau, Tim U. Krohne, Steffen Schmitz-Valckenberg, Frank G. Holz, Monika Fleckenstein; OCT Angiography–Based Detection and Quantification of the Neovascular Network in Exudative AMD. Invest. Ophthalmol. Vis. Sci. 2016;57(14):6342-6348. doi: 10.1167/iovs.16-19741.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the potential of optical coherence tomography (OCT) angiography to detect and quantify the neovascular network in exudative AMD.
Treatment-naïve eyes that were diagnosed with exudative AMD were prospectively examined by OCT angiography (OCT-A). The extent of the neovascular network was measured by three independent readers. Interclass-correlation coefficient and area overlap coefficients (OC) were calculated to assess locally precise agreement between measurements. As a reference for interreader agreement, the extent of the neovascular network was further measured on fluorescein angiography (FA) images.
A total of 31 eyes (27 patients, mean age 82.5 years, 15 female) were included in the study. Neovascularization subtype was classified as type I in 5, type II in 11, type III in 9, and mixed in 6 eyes, respectively. Interreader agreement for measurements of the neovascular network was 0.884 for OCT-A and 0.636 for FA. Overlap coefficient was 0.705 (interquartile [IQR]: 0.450–0.76) for OCT-A and 0.704 (IQR: 0.673–0.750) for FA, respectively. Area agreement was weaker in type III and mixed lesions.
Optical coherence tomography angiography–based measurements of the new vessel complex in neovascular AMD are feasible with interreader agreement comparable with the values obtained for FA. The results underscore the potential of OCT-A as a noninvasive diagnostic tool in neovascular AMD. Yet, further studies will be required to reveal the origin of poor agreement observed in single eyes and to advance OCT-A toward dependable use (e.g., in a reading center context).
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