December 2016
Volume 57, Issue 15
Open Access
Letters to the Editor  |   December 2016
Macular Vascular Flow Area and Vascular Density in Healthy Population Using Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Rodrigo Abreu-Gonzalez
    Department of Ophthalmology, University Hospital of La Candelaria, Tenerife, Canary Islands, Spain.
  • Raqeul Diaz-Rodriguez
    Department of Ophthalmology, University Hospital of La Candelaria, Tenerife, Canary Islands, Spain.
  • Gloria Rubio-Rodriguez
    Department of Ophthalmology, University Hospital of La Candelaria, Tenerife, Canary Islands, Spain.
  • Maria A. Gil-Hernandez
    Department of Ophthalmology, University Hospital of La Candelaria, Tenerife, Canary Islands, Spain.
  • Pedro Abreu-Reyes
    Department of Ophthalmology, University Hospital of La Candelaria, Tenerife, Canary Islands, Spain.
Investigative Ophthalmology & Visual Science December 2016, Vol.57, 6713. doi:10.1167/iovs.16-20359
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      Rodrigo Abreu-Gonzalez, Raqeul Diaz-Rodriguez, Gloria Rubio-Rodriguez, Maria A. Gil-Hernandez, Pedro Abreu-Reyes; Macular Vascular Flow Area and Vascular Density in Healthy Population Using Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(15):6713. doi: 10.1167/iovs.16-20359.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
We read with interest the paper from Coscas et al.1 regarding the normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography (OCT-A). 
The authors state that using the AngioVue OCT-A system (Optovue, Inc., Fremont, CA, USA), the total vascular density in superficial capillary plexus in healthy adults is 52.58 ± 3.22% and for the deep vascular density is 57.87 ± 2.82%. 
Optical coherence tomography angiography technology has some major limitations in clinical practice nowadays: variable segmentation, motion artifact, and project artifact.2 We must take into account that OCT-A manufacturers utilize various algorithms for acquisition, segmentation, and projection removal for their own system. 
The University Hospital of La Candelaria Department of Ophthalmology, Spain, performed an analysis related to the macular vascular flow area and vascular density in a healthy population using the OCT-A Nidek Advance system (Nidek, Aichi, Japan), partially presented at the 5th International SIRCOVA Meeting (July 1 and 2, 2016, Valencia, Spain).3 
We analyzed 18 patients (36 eyes), with a 41.58% male and a 61.42% female composition. Mean age was 48.21 ± 10.76 (range 33–65) years, and spherical equivalent was 0.59 ± 1.9 diopters. A 3 × 3-mm area, centered on the fovea, was scanned for all the study subjects in both eyes. Automated measurement of the vessel flow area and of the density of vessel flow was performed as well in the superficial and in the deep plexus using the Navis-EX software built in into the Nidek OCT-A. Our results are shown in the Table
Table
 
Vessel Flow Area and Density of Vessel Flow of the Superficial and Deep Plexus in Healthy Population
Table
 
Vessel Flow Area and Density of Vessel Flow of the Superficial and Deep Plexus in Healthy Population
In our opinion there is no standard of acquisition, vascular plexus segmentation, and automated measurement among the different OCT-A manufacturers, so we cannot state normative data for vascular density unless we specify a particular OCT-A system. All automated measurement values in OCT-A systems should be considered in relation to the OCT-A system we are using. 
References
Coscas F, Sellam A, Glacet-Bernard A, et al. Normative data for vascular density in superficial and deep capillary plexuses of healthy adults assessed by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016; 57: OCT211–OCT223.
Gao SS, Jia Y, Zhang M, et al. Optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2016; 57: OCT27–OCT36.
Abreu-Gonzalez R, Diaz-Rodriguez R, Abreu-Reyes P, et al. Macular vascular flow area and density in healthy population using optical coherence tomography angiography. 5th Annual SIRCOVA Meeting. Valencia, Spain, July 2016.
Table
 
Vessel Flow Area and Density of Vessel Flow of the Superficial and Deep Plexus in Healthy Population
Table
 
Vessel Flow Area and Density of Vessel Flow of the Superficial and Deep Plexus in Healthy Population
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