June 2017
Volume 58, Issue 7
Open Access
Letters to the Editor  |   June 2017
Author Response: Gap in Capillary Perfusion on Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Kotaro Tsuboi
    Department of Ophthalmology, Aichi Medical University, Nagakute, Japan.
  • Motohiro Kamei
    Department of Ophthalmology, Aichi Medical University, Nagakute, Japan.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3045. doi:10.1167/iovs.17-22130
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      Kotaro Tsuboi, Motohiro Kamei; Author Response: Gap in Capillary Perfusion on Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(7):3045. doi: 10.1167/iovs.17-22130.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
We appreciate the valuable comments from Huang and Sha1 regarding our recent article.2 Their comments raise an important point about image artifacts in optical coherence tomography angiography (OCTA). 
Image artifacts in OCTA are common and physicians should be aware of this problem.3 As reported elsewhere, it is difficult to evaluate precise vascular abnormalities when macular edema is present.4 Thus, in the current study, we described our OCTA protocol in cases in which macular edema persisted.2 In eyes with persistent macular edema, OCTA was performed within 2 months after the last anti-VEGF treatment, when the macular edema was suppressed temporarily. Cases with considerable macular edema after anti-VEGF treatment were excluded. Therefore, we believe that capillary loss in the deep capillary plexus was not an artifact. 
Huang and Sha1 mentioned that a prospective and longitudinal study is important to gain an understanding of the pathogenesis of branch retinal vein occlusion, a statement with which we agree heartily. A prospective study with a larger number of patients is currently underway. We are looking forward to reporting our results in the near future. 
References
Huang W, Sha X. Gap in capillary perfusion on optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2017; 58: 3044.
Tsuboi K, Ishida Y, Kamei M. Gap in capillary perfusion on optical coherence tomography angiography associated with persistent macular edema in branch retinal vein occlusion. Invest Ophthalmol Vis Sci. 2017; 58: 2038–2043.
Spaide RF, Fujimoto JG, Waheed NK. Image artifacts in optical coherence tomography angiography. Retina. 2015; 35: 2163–2180.
Suzuki N, Hirano Y, Yoshida M, et al. Microvascular abnormalities on optical coherence tomography angiography in macular edema associated with branch retinal vein occlusion. Am J Ophthalmol. 2016; 161: 126–132.
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