June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Phototherapeutic keratectomy and matrix ReGeneraTingAgent (RGTA, polycarboxymethyl glucose sulfate ) as a treatment method in patients with corneal erosion syndrome
Author Affiliations & Notes
  • Ewa Mrukwa-Kominek
    Ophthalmology, University Clinical Center, Medical University, Katowice, Poland
  • Anna Bonczar
    Ophthalmology, University Clinical Center, Medical University, Katowice, Poland
  • Agnieszka Urgacz-Lechowicz
    Ophthalmology, University Clinical Center, Medical University, Katowice, Poland
  • Footnotes
    Commercial Relationships   Ewa Mrukwa-Kominek, None; Anna Bonczar, None; Agnieszka Urgacz-Lechowicz, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 167. doi:
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      Ewa Mrukwa-Kominek, Anna Bonczar, Agnieszka Urgacz-Lechowicz; Phototherapeutic keratectomy and matrix ReGeneraTingAgent (RGTA, polycarboxymethyl glucose sulfate ) as a treatment method in patients with corneal erosion syndrome. Invest. Ophthalmol. Vis. Sci. 2017;58(8):167.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Effectiveness of Phototherapeutic keratectomy with simultaneous application of matrix ReGeneraTingAgent (RGTA, polycarboxymethyl glucose sulfate ) as a therapy in recurrent corneal erosion syndrome

Methods : Prospective, randomized study including 35 patients (39 eyes) with recurrent corneal erosion due to corneal dystrophy in which PTK (Group 1 -16 eyes) vs PTK with simultaneous application of the RGTA (Cacicol) eye drops directly after PTK, before contact lens(Group 2 – 23 eyes). Mean age 51.38 (from 29 to 89). Additionally 0,15 % sodium hyaluronate preservative-free lubricating eye drops were used. The mean photoablation area was 6,5 mm. BCVA, time to complete healing, recurrence rate, corneal morphology in confocal microscopy and corneal thickness in anterior segment optical coherent tomography were assessed. The follow-up time was 12 months. BCVA, healing time, recurrence rate, corneal morphology in confocal microscopy and corneal thickness in AS-OCT were assessed

Results : BCVA improvement was noted in 78% of cases in group 1 and 86% in group 2. In both groups the stopped recurrence of corneal erosion and enhanced matrix regeneration were observed. The average time of epithelialization was 2.35 and 1.73 days in group 1 and 2 respectively (p,0.05). Confocal microscopy images showed normal epithelium 7 days after the treatment in 77% of eyes in group 1 and 95% in group 2 (p<0.05); Regular shape of keratocyte below the photoablation area and no objective haze were noticed in 72% and 91% of eyes respectively. No side effects were noted

Conclusions : Regenerating agent improves corneal reepithelialization, is useful, alternative, noninvasive therapeutic approach in patients with recurrent corneal erosion

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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