June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Comparison of Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration
Author Affiliations & Notes
  • Reinhard Told
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Stefan Sacu
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Alexander Hecht
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Magdalena Baratsits
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Katharina Eibenberger
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Maria Elisabeth Kroh
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Sandra Rezar
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Ferdinand Georg Schlanitz
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Andreas Pollreisz
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Reinhard Told, None; Stefan Sacu, Allergan (F), Askin (F), Bayer (F), Novartis (F), Pharma Select (F); Alexander Hecht, None; Magdalena Baratsits, None; Katharina Eibenberger, None; Maria Kroh, None; Sandra Rezar, None; Ferdinand Schlanitz, None; Andreas Pollreisz, None; Ursula Schmidt-Erfurth, Alcon (F), Allergan (F), Bayer (F), Boehringer (F), Novartis (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 18. doi:
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      Reinhard Told, Stefan Sacu, Alexander Hecht, Magdalena Baratsits, Katharina Eibenberger, Maria Elisabeth Kroh, Sandra Rezar, Ferdinand Georg Schlanitz, Andreas Pollreisz, Ursula Schmidt-Erfurth; Comparison of Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):18.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Aiming at neovascular age-related macular degeneration (nAMD) diagnosis and retreatment criteria based on optical coherence tomography (OCTA) needs comprehensive understanding of both, current and new imaging techniques. This study compares indocyanine green angiography (ICGA) and OCTA imaging for detecting choroidal neovascularization (CNV) and CNV area (CNV-A) in patients with type 1 and type 2 nAMD.

Methods : All patients underwent ETDRS visual acuity testing, complete ophthalmic exam with funduscopy as well as, FA, ICGA and OCTA imaging. Detection sensitivity of CNV in type 1 and type 2 nAMD eyes was assessed. Also, CNV-A was compared between ICGA and OCTA in type 1 and type 2 nAMD eyes. All measurements were performed independently by two experienced graders.

Results : 40 eyes of 39 consecutive patients (mean age: 77 ± 6.4 years, 22 female, 17 male) were included. ICGA revealed CNV in all eyes of both type 1 and type 2 nAMD (100% each). In contrast, OCTA detected CNV in 19 eyes with type 1 nAMD (95%) and 16 eyes with type 2 nAMD (80%). Total mean CNV-A was 2.9 ± 2.7 and 2.1 ± 2.7 mm2 in ICGA and OCTA, respectively. Type 1 mean CNV-A was 3.0 ± 3.0 mm2 in ICGA and significantly smaller in OCTA (2.5 ± 3.1 mm2, p< 0.0001, t-test). The same was true for type 2 CNV-A; 2.8 ± 2.4 and 1.8 ± 2.2 mm2 in ICGA and OCTA, respectively (p = 0.0004, t-test).
OCTA failed to show CNV in five eyes (type 1: one eye, type 2: four eyes). When comparing ICGA CNV-A of these five OCTA-negative eyes to the other 35 OCTA-positive eyes, there was no significant difference in ICGA CNV-A size found (p = 0.8). ICC for CNV-A was 0.91.

Conclusions : OCTA detects fewer CNV lesions compared to ICGA. In general, the area of CNV was significantly smaller in OCTA compared to ICGA. This applies to both groups, type 1 and type 2 nAMD. ICGA CNV-A size is not associated with the ability of OCTA to identify neovascular lesions, neither in type 1 nor in type 2 nAMD.
Despite the non-invasive approach of OCTA, further efforts are needed to replace ICGA in the diagnosis of nAMD type 1 and 2.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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