June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Heritability of retinal vascular fractals: a twin study.
Author Affiliations & Notes
  • Anna Stage Vergmann
    Odense University Hospital, Odense C, Denmark
  • Rebecca Broe
    Odense University Hospital, Odense C, Denmark
  • Line Kessel
    University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark
    Department of Ophthalmology, Rigshospitalet - Glostrup, Glostrup, Denmark
  • Jesper Leth Hougaard
    Department of Ophthalmology, Skånes University Hospital, Malmö, Sweden
  • Kirsten Ohm Kyvik
    Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  • Michael Larsen
    University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark
    Department of Ophthalmology, Rigshospitalet - Glostrup, Glostrup, Denmark
  • Inger Christine Munch
    University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark
    Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark
  • Jakob Grauslund
    Odense University Hospital, Odense C, Denmark
  • Footnotes
    Commercial Relationships   Anna Stage Vergmann, None; Rebecca Broe, None; Line Kessel, None; Jesper Leth Hougaard, None; Kirsten Ohm Kyvik, None; Michael Larsen, None; Inger Christine Munch, None; Jakob Grauslund, None
  • Footnotes
    Support  The study was supported by grants from the Novo Nordic Foundation for Research in Biotechnology and Pharmaceutical Sciences, the Danish Diabetes Association, the Danish Heart Foundation, the Danish Medical Research Council, the Danish National Science Foundation (Grundforskningsfonden), Fight for Sight Denmark, and The Danish Eye Research Foundation.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 180. doi:
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      Anna Stage Vergmann, Rebecca Broe, Line Kessel, Jesper Leth Hougaard, Kirsten Ohm Kyvik, Michael Larsen, Inger Christine Munch, Jakob Grauslund; Heritability of retinal vascular fractals: a twin study.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):180.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the genetic contribution to the pattern or retinal vascular branching as expressed by its fractal dimension.

Methods : This was a cross-sectional study of 59 monozygotic (MZ ) and 55 dizygotic (DZ), same-gender twin pairs aged 20-46 years. In a 50-degree, disc-centred fundus photograph, the fractal dimension was evaluated by a trained grader using the box-counting method in the SIVA-Fractal software version 1.0 (National University of Singapore, Singapore). The fractal dimension was compared within MZ and DZ twin pairs using Pearson correlation coefficents. To determine the genetic component, we used Falconer’s formula to calculate the heritability, h2.

Results : Retinal vascular fractals were gradable for both twins in 50 MZ and 49 DZ twin pairs. Median age was 36 years (range 20 to 46 years), and 44% were male. The mean fractal dimension was 1.505 (SD 0.0287) and 1.495 (SD 0.0324) for MZ and DZ twins, respectively. The Pearson correlation coefficient between twin A and twin B was 0.50 (p=0.0002) for MZ twins and 0.11 (p=0.46) for DZ twins. The heritability h2 for the fractal dimension was 0.79.

Conclusions : The branching pattern of retinal vessels as depicted on fundus photographs of healthy young twins demonstrated a higher likeness between monozygotic twins than between dizygotic twins. The likeness parameter, fractal dimension, was determined largely by genetic factors.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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