June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Changes in the foveal avascular zone in maculopathy patients with intravitreal anti-VEGF injection observed by optical coherence tomography angiography
Author Affiliations & Notes
  • Xun Xu
    Department of Ophthalmology, Shanghai First People's Hospital, Shanghai, China
  • Kun Liu
    Department of Ophthalmology, Shanghai First People's Hospital, Shanghai, China
  • Footnotes
    Commercial Relationships   Xun Xu, None; Kun Liu, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 20. doi:
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      Xun Xu, Kun Liu; Changes in the foveal avascular zone in maculopathy patients with intravitreal anti-VEGF injection observed by optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):20.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare optical coherence tomography angiography (OCTA) and fluorescein angiography (FA)for measurement of the foveal avascular zone (FAZ) in healthy eyes and in maculopathy eyes, and to evaluate the short-term impact of anti-VEGF treatment on the FAZ area and density in maculopathy patients by sequential OCTA observation.

Methods : Forty-nine patients (49 eyes) with unaffected eyes and sixty patients (70 eyes) with maculopathy eyes were scanned with OCTA and FA. Superficial and deep FAZ areas recorded by OCTA and FA were independently examined by two observers. In addition, the size and density of FAZ areas in the eyes of 21 patients with maculopathy undergoing intravitreal injection with anti-VEGF drugs were measured by OCTA before injection (baseline), and at 1 hour, 1 week, and 1 month after injection.

Results : OCTA revealed clear, detailed capillary networks around the FAZ in healthy eyes and in diseased eyes. Inter-observer reproducibility of FAZ area measurements was high for all retina layers in normal eyes by OCTA and FA (CCC>0.9). However, the only high correlation between the measurements by Grader1 and Grader2 was on the OCTA superficial 3 mm×3 mm area and FA in maculopathy eyes (CCC 0.974 0.969). The CCC for OCTA and FA were high for FAZ measurements within a superficial 3 × 3mm area in healthy eyes and maculopathy eyes (CCC=0.974 and 0.938, respectively). In the 21 eyes with maculopathy that received intravitreal anti-VEGF injection, there was no significant difference in the area and density of FAZ (P>0.05) at one month by OCTA, which suggests that anti-VEGF treatment has little effect on FAZ size.

Conclusions : Compared to FA, OCTA is a more effective multiple-layer imaging technique for detecting changes in FAZ areas in normal and pathological eyes with high repeatability and accuracy.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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