June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Choroidal Thickness May Be Associated with Serum Placental Growth Factor in Women with Severe Preeclampsia
Author Affiliations & Notes
  • Victoria North
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States
  • Conrad Stern-Ascher
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States
    Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States
  • Aakriti Garg
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States
  • Winston Lee
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States
  • Cande Ananth
    Obstetrics and Gynecology , Columbia University College of Physicians and Surgeons, New York, New York, United States
    Epidemiology, Joseph L. Mailman School of Public Health at Columbia University, New York, New York, United States
  • Ronald Wapner
    Obstetrics and Gynecology , Columbia University College of Physicians and Surgeons, New York, New York, United States
  • Srilaxmi Bearelly
    Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York, United States
    Obstetrics and Gynecology , Columbia University College of Physicians and Surgeons, New York, New York, United States
  • Footnotes
    Commercial Relationships   Victoria North, None; Conrad Stern-Ascher, None; Aakriti Garg, None; Winston Lee, None; Cande Ananth, None; Ronald Wapner , None; Srilaxmi Bearelly, None
  • Footnotes
    Support  New York Community Trust-­‐Frederick J. and Theresa Dow Wallace Fund; Research to Prevent Blindness; The Robert L. Burch III Scholarship
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 244. doi:
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      Victoria North, Conrad Stern-Ascher, Aakriti Garg, Winston Lee, Cande Ananth, Ronald Wapner, Srilaxmi Bearelly; Choroidal Thickness May Be Associated with Serum Placental Growth Factor in Women with Severe Preeclampsia. Invest. Ophthalmol. Vis. Sci. 2017;58(8):244.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Levels of placental growth factor (PlGF), a proangiogenic factor made by the placenta, increase early in pregnancy but later fall as soluble VEGF receptor (sFlt-1) levels increase. These changes occur earlier and are more pronounced in preeclampsia. Our purpose is to determine if an association exists between PlGF and choroidal thickness (CT) in women with severe preeclampsia (sPE).

Methods : This is an IRB-approved, prospective cohort study of 30 women with sPE and 37 normotensive controls matched by ethnicity and parity and recruited in the immediate postpartum period. Exclusion criteria included chronic or gestational hypertension and diabetes. All subjects underwent enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). Heidelberg Eye Explorer software was used to measure CT (µm). ELISA was used to measure serum PlGF (pg/ml).

Results : PlGF did not differ significantly between groups (21.16 ± 7.93 pg/ml in cases vs. 18.73 ± 6.42 pg/ml in controls, p = 0.169). Amongst cases, CT was correlated with PlGF (r2 = 0.280, p = 0.004 OD; r2 = 0.228, p = 0.010 OS). No correlation was seen in controls (r2 = 0.027, p = 0.339).

Conclusions : Though serum PlGF levels do not differ significantly between postpartum women with severe preeclampsia and those with normotensive pregnancies, choroidal thickness is more strongly associated with PlGF in cases as compared to controls. Further studies of serum markers of preeclampsia could help identify women at risk of developing more severe eye disease.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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