June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Evaluation of Coronary Heart Disease as a Risk Factor for Sight Threatening Reticular Pseudodrusen.
Author Affiliations & Notes
  • Rachel Victoria McCarter
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Gareth J McKay
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Nicola B Quinn
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Usha Chakravarthy
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Tom MacGillivray
    VAMPIRE project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom
  • Gavin Robertson
    VAMPIRE project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom
  • Enrico Pellegrini
    VAMPIRE project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom
  • Emanuele Trucco
    VAMPIRE project, Computing, School of Science and Engineering, University of Dundee, Dundee, United Kingdom
  • Michelle Williams
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
  • Tunde Peto
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Baljean Dhillon
    VAMPIRE project, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom
  • Edwin van Beek
    Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom
  • David E Newby
    Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
  • Ruth E Hogg
    Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom
  • Footnotes
    Commercial Relationships   Rachel McCarter, None; Gareth McKay, None; Nicola Quinn, None; Usha Chakravarthy, None; Tom MacGillivray, None; Gavin Robertson, None; Enrico Pellegrini, None; Emanuele Trucco , None; Michelle Williams , None; Tunde Peto, None; Baljean Dhillon , None; Edwin van Beek , None; David Newby , None; Ruth Hogg, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 27. doi:
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      Rachel Victoria McCarter, Gareth J McKay, Nicola B Quinn, Usha Chakravarthy, Tom MacGillivray, Gavin Robertson, Enrico Pellegrini, Emanuele Trucco, Michelle Williams, Tunde Peto, Baljean Dhillon, Edwin van Beek, David E Newby, Ruth E Hogg; Evaluation of Coronary Heart Disease as a Risk Factor for Sight Threatening Reticular Pseudodrusen.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):27.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Reticular pseudodrusen (RPD) has been identified as a strong risk factor for the late stages of age-related macular degeneration (AMD). Associations between RPD and coronary heart disease (CHD) have also been reported, mainly from small case-control studies carried out in ophthalmic clinics. This study investigated the association of CHD as a risk factor for RPD within a predominantly CHD cohort.

Methods : This study used data from the SCOT-HEART trial, a multicentre randomised controlled trial investigating the additional benefit of computed tomography coronary angiography and calcium scores compared to standard care on patients who were being assessed for suspected angina due to CHD. CHD was categorised as mild, moderate or obstructive. Data was used from a sub-study in which 534 participants in Edinburgh and Dundee had ultra-widefield (UWF) retinal imaging acquired with an Optos P200C scanning laser ophthalmoscope in addition to the normal trial procedures. At least one eye was gradable from 532 participants. Specific features of AMD in UWF images were graded according to the ‘Study-specific Grading Procedures for Optos Peripheral Retina AMD (OPERA) study,’ guidelines. Standardised grading grids were used to record the spatial location of AMD features, including the presence of RPD. Multiple variable confounder adjusted regression models were used to assess the association between RPD and CHD.

Results : The 534 participants ranged in age from 27-75 years (mean 58 years. SD 9.52); 56% were male and 425 (80%) ≥50 years. Within the study sample, 178 (33.3%) had no CHD, 182 (34.1%) had hypertension and 42 (24.4%) had neither CHD nor hypertension. RPD was prevalent in 30 participants (5.63%) and out of this group was bilaterally present in 23. Most participants with bilateral RPD also had drusen > 125µm (early AMD) present. Logistic regression analysis indicated after the adjustment for potential confounders (age, gender, smoking habit, drusen > 125µm) that there was no significant association between CHD and RPD (odds ratio [OR] 0.97; 95% Confidence Interval [CI] (0.39-2.43); p= 0.95). There was a significant association between RPD and drusen >125µm (OR 2.69; 95% CI (1.11-6.49); p= 0.03).

Conclusions : From the data analysed there appears little evidence of a relationship between CHD and RPD. As in other studies, when present, RPD was often associated with early AMD features.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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