June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Correlation of cone spacing with retinal thickness and microperimetry in patients with inherited retinal degenerations and healthy subjects
Author Affiliations & Notes
  • Katharina G Foote
    University of California, Berkeley, Berkeley, California, United States
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Irina De la Huerta
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Kevin Gustafson
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Angela Baldwin
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Shiri Zayit-Soudry
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Jia Qin
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Nicholas Rinella
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Travis C Porco
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Austin Roorda
    University of California, Berkeley, Berkeley, California, United States
  • Jacque L. Duncan
    Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Katharina Foote, None; Irina De la Huerta, None; Kevin Gustafson, None; Angela Baldwin, None; Shiri Zayit-Soudry, None; Jia Qin, None; Nicholas Rinella, None; Travis Porco, None; Austin Roorda, University of Houston (P), University of Rochester (P); Jacque Duncan, None
  • Footnotes
    Support  NIH grant EY023591; NIH grant EY014375; NIH grant EY002162; FDA grant R01-41001; Foundation Fighting Blindness; Research to Prevent Blindness; Claire Giannini Foundation; L.L. Hillblom Foundation; That Man May See, Inc.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 310. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Katharina G Foote, Irina De la Huerta, Kevin Gustafson, Angela Baldwin, Shiri Zayit-Soudry, Jia Qin, Nicholas Rinella, Travis C Porco, Austin Roorda, Jacque L. Duncan; Correlation of cone spacing with retinal thickness and microperimetry in patients with inherited retinal degenerations and healthy subjects. Invest. Ophthalmol. Vis. Sci. 2017;58(8):310.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : The current study proposes to use high resolution measures of macular structure and function over 36 months in patients with retinal degeneration (RD) and age-similar normal subjects.

Methods : 4 eyes of 4 patients with RD and 10 eyes from 6 healthy subjects were studied at baseline and 36 months later. Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) was used to image the central 5 degrees. Regions of interest (ROIs) with unambiguous cones were chosen to measure cone spacing by 1-2 graders in random order using a density recovery profile. AOSLO images were precisely aligned with images acquired with spectral-domain optical coherence tomography (SD-OCT, Spectralis, Heidelberg Engineering, CA, USA) and fundus-guided microperimetry (MP1, Nidek, CA, USA) images to permit correlation between measures of retinal structure and function. SD-OCT images were segmented manually to measure inner and outer segment (IS and OS) length at locations corresponding to ROIs. Fundus guided microperimetry was measured in the central 10 degrees. 8-12 ROIs were used from each montage that corresponded to horizontal and vertical SD-OCT scans acquired through the fovea. Correlations between cone spacing, OS, IS length, and sensitivity were assessed using Huber robust regression.

Results : 41 ROIs from patients and 98 ROIs from healthy eyes were measured. Cone spacing was inversely correlated with IS length (P = 0.0007), and OS length (P=0.0002) when all eyes were analyzed together. Cone-mediated sensitivity was not significantly correlated with cone spacing (P = 0.2). We detected no significant change in cone spacing, IS or OS length or MP1 sensitivity over 36 months in the 4 patients studied.

Conclusions : Cone spacing correlated with IS and OS length in all subjects, but not with cone mediated sensitivity. Cone spacing increases with eccentricity in the macula but sensitivity is stable throughout the central macula in normal eyes due to a ceiling effect, possibly accounting for the lack of correlation between cone spacing and sensitivity. Although we observed no significant change over 36 months in this small study, the correlations observed suggest that high resolution images of cone structure can be used to assess patients with RD over time, proving they may be appropriate outcome measures for clinical trials.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×