June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical coherence tomography angiography changes in early type 3 neovascularization after anti-VEGF treatment
Author Affiliations & Notes
  • Alexandra Miere
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Giuseppe Querques
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
    Ophthalmology, University Vita-Salute San Raffaele , Milan, Italy
  • Oudy Semoun
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Francesca Amoroso
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Olivia Zambrowski
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • thibaut Chapron
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Vittorio Capuano
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Eric Souied
    Ophthalmology, Centre Hospitalier intercommunal de Creteil, Creteil, France
  • Footnotes
    Commercial Relationships   Alexandra Miere, None; Giuseppe Querques, None; Oudy Semoun, None; Francesca Amoroso, None; Olivia Zambrowski, None; thibaut Chapron, None; Vittorio Capuano, None; Eric Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 377. doi:
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      Alexandra Miere, Giuseppe Querques, Oudy Semoun, Francesca Amoroso, Olivia Zambrowski, thibaut Chapron, Vittorio Capuano, Eric Souied; Optical coherence tomography angiography changes in early type 3 neovascularization after anti-VEGF treatment. Invest. Ophthalmol. Vis. Sci. 2017;58(8):377.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the morphological changes after anti-vascular endothelial growth factor (VEGF) therapy of treatment naive type 3 neovascularization secondary to exudative age-related macular degeneration (AMD), using optical coherence tomography angiography (OCTA).

Methods : In this retrospective study we included consecutive patients diagnosed with treatment-naïve early-stage type 3 neovascularization. All patients underwent fluorescein angiography (FA), indocyanine green angiography (ICGA), structural spectral-domain (SD)-OCT, and OCTA Optovue RTVue® XR Avanti (Optovue, Freemont, California, USA) at baseline, and repeated OCTA and structural SD-OCT at month 12. 3x3 OCTA examinations at baseline and month 12 were then compared, in order to qualitatively assess changes after anti-VEGF therapy.

Results : Fifteen treatment-naïve eyes of 15 consecutive patients were enrolled in the analysis. At 12 months follow-up after pro-re-data anti-VEGF therapy (5.75+/-1.48 injections of Ranibizumab, and 6.33+/- 1.21 injections of Aflibercept), OCTA demonstrated persistence of the deep capillary plexus abnormalities in 13/15 eyes. In the outer retina and choriocapillaris segmentations the initial lesion became undetectable in 7/15 cases, accompanied by choriocapillaris atrophy. The abnormal vascular complex persisted in the form of a tuft-shaped lesion in the outer retinal segmentation in 9/15 eyes, which in the choriocapillaris segmentation was associated with sub-RPE neovascularization in 8 cases.

Conclusions : OCTA showed that the tuft-shaped abnormal outer retinal lesion, frequently associated to a small clew-like flow signal in the choriocapillaris, either becomes undetectable or develops sub-RPE neovascularization after 1 year of anti-VEGF therapy.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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