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Sean Pitetta, Muneeswar Gupta Nittala, Amir H Hariri, Swetha Velaga, Srinivas R Sadda; Effect of Drusen Volume Index on Geographic Atrophy Progression in Subjects with Dry Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):380.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relationship between optical coherence tomography (OCT) - derived drusen volume index (DVI) and the progression of geographic atrophy (GA) secondary to dry age related degeneration (AMD).
One hundred and four eyes of 104 subjects with dry AMD were enrolled in this IRB approved retrospective study. Baseline and month 18 follow up Spectral Domain-OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Inc., Dublin, CA) images were captured using 512x128 scan protocols at the Doheny Eye Centers-UCLA. Drusen volume (5 mm circles centered on the fovea) and geographic atrophy area (in a central 5 mm circle) were measured using an FDA-cleared automated algorithm (Cirrus OCT Advanced RPE analysis). Drusen volume index (DVI) was calculated by using the formula “DVI = Drusen volume /19.63 X GA area."
Drusen volume index and total GA area significantly increased from baseline to month 18 (DVI; 0.004 ± 0.007 vs. 0.008 ± 0.013, p = 0.001) and (GA; 6.60 ± 4.1 vs. 8.82 ± 4.43, p < 0.001), whereas drusen volume was not significantly different at month 18 when compared to baseline (0.05 ± 0.08 vs. 0.06 ± 0.08, p = 0.07). Neither baseline DV (r –0.008; p = 0.94), baseline DVI (r –0.005; p = 0.96) nor 18-month change in DVI (r -0.13; p = 0.20) were significantly correlated with progression of GA.
Drusen volume index can be used as to monitor the progression rate of drusen burden in eyes with concomitant geographic atrophy. GA progression rate was not significantly impacted by drusen volume or drusen volume index.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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