June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal pigment epithelial features indicative of neovascular progression in age-related macular degeneration
Author Affiliations & Notes
  • Stefan Sacu
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Philipp Ken Roberts
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Bernhard Baumann
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ferdinand Georg Schlanitz
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Matthias Bolz
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Michael Hagmann
    Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria
  • Christoph K Hitzenberger
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships   Stefan Sacu, None; Philipp Roberts, None; Bernhard Baumann, None; Ferdinand Schlanitz, None; Matthias Bolz, None; Michael Pircher, None; Michael Hagmann, None; Christoph Hitzenberger, Canon (Tokyo, Japan) (F), FP7 HEALTH program grant 201880, FUN-OCT, Brussels, Belgium (F), FWF grant P19624-B02, Austrian Science Fund, Vienna, Austria (F); Ursula Schmidt-Erfurth, Allergan (C), Bayer (C), Boehringer Ingelheim (C), Novartis (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 389. doi:
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      Stefan Sacu, Philipp Ken Roberts, Bernhard Baumann, Ferdinand Georg Schlanitz, Matthias Bolz, Michael Pircher, Michael Hagmann, Christoph K Hitzenberger, Ursula Schmidt-Erfurth; Retinal pigment epithelial features indicative of neovascular progression in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):389.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify characteristic retinal pigment epithelium (RPE) changes in fellow eyes of patients with neovascular age-related macular degeneration (nAMD) using polarization-sensitive optical coherence tomography (PS-OCT).

Methods : Thirty-one fellow eyes of 31 patients with unilateral nAMD were evaluated in this cohort study of a prospective interventional trial. PS-OCT as well as conventional imaging systems including spectral-domain (SD-) OCT and fluorescein angiography (FA) were performed using a standardized protocol. Monitoring visits were performed continuously at one-month intervals. Morphological RPE features associated with the development of choroidal neovascularization (CNV) were systematically analyzed.

Results : Mean follow-up was 29 months (±17, SD). Thirteen (42%) of 31 eyes developed de novo CNV: 9 eyes type I CNV, 2 eyes type II CNV, 2 eyes a RAP lesion. RPE thickening and reticular pseudodrusen (RPD) were observed significantly more often in eyes, which progressed towards CNV than in eyes, which did not progress (p=0.008 and p=0.001). Monthly increase in drusen volume was higher in the CNV group with a median increase of +2.2% in area and +2.9% in volume compared with +0.8% and +0.6% in the non-progressing group. RPE migration within the neurosensory retina and at the level of the RPE layer resulting in RPE thickening was seen topographically and chronologically associated with CNV development.

Conclusions : Conversion to CNV is associated with qualitative (RPD, RPE migration, RPE thickening) and quantitative RPE characteristics (drusen volume). Early detection of these features may allow more efficient screening in risk eyes and timely vision-preserving treatment in eyes developing neovascular disease.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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