June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography reproductibility and agreement of lesion size measurements in Neovascular Age Related Macular Degeneration
Author Affiliations & Notes
  • Oudy Semoun
    CHI de Creteil, Creteil, France
  • Francesca Amoroso
    CHI de Creteil, Creteil, France
  • Alexandra Miere
    CHI de Creteil, Creteil, France
  • Camille JUNG
    CHI de Creteil, Creteil, France
  • Vittorio Capuano
    CHI de Creteil, Creteil, France
  • Eric Souied
    CHI de Creteil, Creteil, France
  • Footnotes
    Commercial Relationships   Oudy Semoun, None; Francesca Amoroso, None; Alexandra Miere, None; Camille JUNG, None; Vittorio Capuano, None; Eric Souied, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 394. doi:
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      Oudy Semoun, Francesca Amoroso, Alexandra Miere, Camille JUNG, Vittorio Capuano, Eric Souied; Optical Coherence Tomography Angiography reproductibility and agreement of lesion size measurements in Neovascular Age Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):394.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularization in optical coherence tomography angiography (OCT-A), given that OCT-A provides a non-anatomical measurement of flow within choroidal neovascular lesions.



Methods : Prospective non interventional study. Consecutive patients, presenting with neovascular age related macular degeneration (AMD), underwent two sequential OCT-A examinations (AngioVue, Optovue Inc., Freemont, California), performed by the same trained examiner. Neovascular lesion area was then measured on both examinations in the choriocapillaris automatic segmentation by two masked readers, using the semiautomated measuring software embedded in the instrument. Two measuring features were used: the first corresponding to the total manually contoured lesion area with the flow draw tool (select area) and the second to the total area of solely vessels with high flow within the lesion (vessel area). These measurements were then compared in order to assess both the reproducibility of OCT-A examination and the inter-user agreement with the embedded software.

Results : Fourty-eight eyes of 46 patients (77.4 mean age, +/- 8.2 SD, range from 62 to 95 years old, 8 males, 38 females) were included in our study. Mean choroidal neovascularization area was of 0.72 +/- 0.7 mm2 for the first measure and 0.75 +/- 0.76 mm2 for the second measure; mean difference between the first and the second measurement was 0.73 mm2. Intra-user agreement was of 0.98 (confidence interval 0.98-0.99) for both “vessel area” and “select area” features. Inter-user agreement was of 0.98 (confidence interval 0.97-0.99) for “select area” and “vessel area” features.

Conclusions : Our data suggests that OCT-A is a reproducible examination for the neovascular size in the context of neovascular AMD.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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