June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Difference between polypoidal choroidal vasculopathy and age-related macular degeneration in spectral domain OCT: from the perspective of choroidal vascular architecture
Author Affiliations & Notes
  • Chen-Jin Jin
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Kunbei Lai
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Lijun Zhou
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Shanshan Yu
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Chuangxin Huang
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Xiaojing Zhong
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Lu Lin
    Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China
  • Footnotes
    Commercial Relationships   Chen-Jin Jin, None; Kunbei Lai, None; Lijun Zhou, None; Shanshan Yu, None; Chuangxin Huang, None; Xiaojing Zhong, None; Lu Lin, None
  • Footnotes
    Support  National Nature Science Foundation of China(81670866}
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 45. doi:
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      Chen-Jin Jin, Kunbei Lai, Lijun Zhou, Shanshan Yu, Chuangxin Huang, Xiaojing Zhong, Lu Lin; Difference between polypoidal choroidal vasculopathy and age-related macular degeneration in spectral domain OCT: from the perspective of choroidal vascular architecture. Invest. Ophthalmol. Vis. Sci. 2017;58(8):45.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the differences of choroidal vascular architecture in spectral domain optical coherence tomography (SD-OCT) between polypoidal choroidal vasculopathy (PCV) and neovascular AMD (nAMD) patients.

Methods : SD-OCT images in 189 eyes (189 patients) with macula-involved PCV (n=107) and nAMD (n=82) were reviewed retrospectively. The subfoveal choroidal thickness including the choriocapillaris/medium choroidal vessel layer and the large choroidal vessel layer (the Haller layer), as well as the mean maximum diameters of large choroidal vessel under macular were measured and compared between two groups.

Results : The total subfoveal choroidal thickness of the PCV group and the nAMD group were 257.31±100.50μm and 209.95±97.51μm, respectively (P<0.01). And the ratio of subfoveal large choroidal vessel layer thickness/total choroidal thickness (0.83±0.07) in the PCV group was significantly higher than that in nAMD group (0.75±0.11) (P<0.01). Similar results were found in the mean maximum diameters of large choroidal vessel between two groups (163.55±62.23μm vs. 112.81±58.87μm) (P<0.01).

Conclusions : Choroidal thickening (pachychoroid), as well as vasodilation of the Haller layer were significantly more common in PCV patients than that in nAMD patients, suggesting that PCV and AMD might be two different entities, at least from the perspective of choroidal vascular architecture.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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