June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial
Author Affiliations & Notes
  • Miguel Ângelo Costa
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Luísa Ribeiro
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Jose Garcia-Arumi
    Department of Ophthalmology, Vall d’Hebron University Hospital, Barcelona, Spain
  • Peter Scanlon
    Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom
  • Jakob Grauslund
    Department of Clinical Research, Research Unit of Ophthalmology, University of Southern Denmark, Odense, Denmark
  • Francesco Bandello
    Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy
  • Jonathan Gibson
    Department of Vision Sciences, Aston University, Birmingham, United Kingdom
  • Edoardo Midena
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Gabriele Elisabeth Lang
    Department of Ophthalmology, University of Ulm, Ulm, Germany
  • Simon P Harding
    Department of Eye & Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
  • Catherine A Egan
    Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom
  • Pascale Massin
    Department of Ophthalmology, Lariboisière Hospital, Paris, France
  • Torcato Santos
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Berta Ponsati
    BCN Peptides, Barcelona, Spain
  • Jose G Cunha-Vaz
    AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal
  • Rafael Simó
    Diabetes and Metabolism Research Unit and CIBERDEM, Vall d’Hebron Research Institute, Barcelona, Spain
  • Footnotes
    Commercial Relationships   Miguel Costa, None; Luísa Ribeiro, None; Jose Garcia-Arumi, None; Peter Scanlon, None; Jakob Grauslund, None; Francesco Bandello, Alcon (C), Alimera Science (C), Allergan (C), BAUSCH&LOMB (C), Bayer (C), BOEHRINGER-INGELHEIM (C), FARMILA THEA (C), GENENTECH (C), HOFFMANN LA ROCHE (C), NOVAGALI PHARMA (C), NOVARTIS (C), SANOFI AVENTIS (C), SIFI (C), SOOFT (C), THROMBOGENICS (C), ZEISS (C); Jonathan Gibson, None; Edoardo Midena, None; Gabriele Lang, None; Simon Harding, None; Catherine Egan, None; Pascale Massin, None; Torcato Santos, None; Berta Ponsati, None; Jose Cunha-Vaz, Alimera Sciences (C), Allergan (C), Bayer (C), Fovea Pharmaceuticals (C), GeneSignal (C), Novartis (C), OM Pharma (C), Pfizer (C), Roche (C), Zeiss (C); Rafael Simó, None
  • Footnotes
    Support  European Union 7th Framework Programme EC-FP7-278040, Grant agreement number 278040
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 62. doi:
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      Miguel Ângelo Costa, Luísa Ribeiro, Jose Garcia-Arumi, Peter Scanlon, Jakob Grauslund, Francesco Bandello, Jonathan Gibson, Edoardo Midena, Gabriele Elisabeth Lang, Simon P Harding, Catherine A Egan, Pascale Massin, Torcato Santos, Berta Ponsati, Jose G Cunha-Vaz, Rafael Simó; Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial. Invest. Ophthalmol. Vis. Sci. 2017;58(8):62.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify the involvement of the different retinal layers in subclinical and center-involving macular edema in a large cohort type 2 diabetic eyes with early diabetic retinopathy (DR) or without DR.

Methods : A cohort of 449 type II diabetic eyes/patients with mild non-proliferative DR (ETDRS levels 20 or 35), 57% of eyes, or without DR (ETDRS level 10), 43% of eyes, (EUROCONDOR clinical trial, NCT01726075) were examined with SD-OCT at the baseline visit. Automated segmentation of the retinal layers was compared with a sample of 58 healthy eyes from a control group.

Results : From the 449 eyes of the study 48% had normal baseline full retinal thickness, 30% had subclinical macular edema and 5% had center-involving macular edema, using the DRCR.net parameters. The highest increases in retinal thickness (RT) were found in the inner nuclear layer (INL; 53% in subclinical macular edema, p<0.001 and 91% in center-involving macular edema, p<0.001). Statistically significant increases (p<0.001) were also found in the immediately neighboring layers (GCL+IPL and ONL) on patients with subclinical and center-involving macular edema. Thinning of the retina was registered in the RNF and OS layers in the diabetic eyes with normal full retinal thickness at baseline.

Conclusions : The increase in RT occurring in diabetic eyes with different degrees of macular edema is predominantly located in the INL but extends to immediately neighboring retinal layers indicating that it may be due to extracellular fluid accumulation resulting from increased vascular permeability in the retinal deep capillary layer.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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