June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
CORRELATION ANALYSIS BETWEEN FOVEAL AVASCULAR ZONE AND PERIPHERAL ISCHEMIC INDEX IN DIABETIC RETINOPATHY: A PILOT STUDY
Author Affiliations & Notes
  • Luigi Capone
    Vita-Salute San Raffaele University, Milano, Italy
  • Alessandro Rabiolo
    Vita-Salute San Raffaele University, Milano, Italy
  • Maria Vittoria Cicinelli
    Vita-Salute San Raffaele University, Milano, Italy
  • Eleonora Corbelli
    Vita-Salute San Raffaele University, Milano, Italy
  • Giovanni Baldin
    Vita-Salute San Raffaele University, Milano, Italy
  • Adriano Carnevali
    Vita-Salute San Raffaele University, Milano, Italy
    University Magna Graecia, Catanzaro, Italy
  • Rosangela Lattanzio
    Vita-Salute San Raffaele University, Milano, Italy
  • Lea Querques
    Vita-Salute San Raffaele University, Milano, Italy
  • Giuseppe Querques
    Vita-Salute San Raffaele University, Milano, Italy
  • Francesco Bandello
    Vita-Salute San Raffaele University, Milano, Italy
  • Footnotes
    Commercial Relationships   Luigi Capone, None; Alessandro Rabiolo, None; Maria Vittoria Cicinelli, None; Eleonora Corbelli, None; Giovanni Baldin, None; Adriano Carnevali, None; Rosangela Lattanzio, None; Lea Querques, None; Giuseppe Querques, Alimera Sciences (C), Allergan Inc (C), Bayer Shering.Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C); Francesco Bandello, Alcon (C), Allergan Inc (C), Bausch And Lomb (C), Bayer Shering-Pharma (C), Famila-Thea (C), Genetech (C), Hoffmann-La-Roche (C), NovagaliPharma (C), Novartis (C), Sanofi-Aventis (C), Thrombogenics (C), Zeiss (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 74. doi:
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      Luigi Capone, Alessandro Rabiolo, Maria Vittoria Cicinelli, Eleonora Corbelli, Giovanni Baldin, Adriano Carnevali, Rosangela Lattanzio, Lea Querques, Giuseppe Querques, Francesco Bandello; CORRELATION ANALYSIS BETWEEN FOVEAL AVASCULAR ZONE AND PERIPHERAL ISCHEMIC INDEX IN DIABETIC RETINOPATHY: A PILOT STUDY. Invest. Ophthalmol. Vis. Sci. 2017;58(8):74.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the foveal avascular zone (FAZ) by optical coherence tomography angiography (OCT-A) in patients affected by diabetic retinopathy (DR) and its correlation with peripheral retinal ischemic index (ISI).

Methods : All patient underwent a comprehensive ocular examination including optical coherence tomography (OCT), OCT-A, ultra-widefield (UWF) retinography and UWF fluorescein angiography.

Results : Twenty-one eyes of 14 patients (7 males, mean age 56.1 ± 14.4 years) were included. Mean ftFAZ, sFAZ and dFAZ areas were 0.320 ± 0.130 mm2, 0.325 ± 0.162 mm2 and 0.840 ± 0.329 mm2, respectively. Mean ISI was 14.6 % (range 0%-49.7%). A significant correlation was found between ISI and both ftFAZ (p = 0.0065) and sFAZ (p = 0.0052). DR grading correlated to ISI (p = 0.0053), ftFAZ (p = 0.0106), and sFAZ (p = 0.0119) areas. No significant correlation between ISI and dFAZ was appreciated. BCVA correlated to no variable other than CMT (p = 0.0003).

Conclusions : The association between peripheral and macular perfusion found in this study supports the hypothesis that both these condition share a common pathogenic mechanism that is capillary non-perfusion

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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