June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Can cell-based therapy in patients with optic atrophy be considered a biological visual rehabilitation?
Author Affiliations & Notes
  • Paolo G. Limoli
    Low Vision Research Center of Milan, Milan, Italy
  • Marcella Nebbioso
    Department of Sense Organs, Sapienza University of Rome, Rome, Italy
  • Enzo Maria Vingolo
    Department of Ophthalmology, A. Fiorini Hospital, Terracina, Polo Pontino, Sapienza University of Rome, Rome, Italy, Italy
  • Marco U Morales
    Division of Clinical Neurosciences, Academic Ophthalmology, University of Nottingham, Nottingham, United Kingdom
  • Celeste Limoli
    Low Vision Research Center of Milan, Milan, Italy
  • Sergio Zaccaria Scalinci
    Medical and Surgical Science Departement, Policlinico S. Orsola-Malpighi - University of Bologna, Bologna, Italy
  • Footnotes
    Commercial Relationships   Paolo Limoli, None; Marcella Nebbioso, None; Enzo Maria Vingolo, None; Marco Morales, None; Celeste Limoli, None; Sergio Zaccaria Scalinci, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1365. doi:
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      Paolo G. Limoli, Marcella Nebbioso, Enzo Maria Vingolo, Marco U Morales, Celeste Limoli, Sergio Zaccaria Scalinci; Can cell-based therapy in patients with optic atrophy be considered a biological visual rehabilitation?. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1365.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optic atrophy (OA) is usually the end-stage of many diseases of the optic nerve. Up-to-date optical magnification devices are the only option to improve visual abilities in patients with OA. Recent studies have reported that growth factors (GF), directly or in cell-mediated mode, can be responsible for neuroenhancement effects. Among different techniques, Limoli Retinal Restoration Technique (LRRT), builds a suprachoroidal autograft of adipocytes, adipose-derived stem cells and platelets, able to produce directly into the choroidal space GF and, consequently, retinal neuroenhancement. We performed a retrospective, observational clinical study to explore changes in the visual function of patients with OA treated with LRRT.

Methods : Inclusion criteria was stabilized OA. Exclusion criteria the coexistence of other eye diseases like high myopia, retinitis pigmentosa, cataract, macular degeneration, or very disabling brain disorders. 33 eyes of 20 low vision patients (15 males and 5 females), mean age of 43.12 years (range 16-84), were recruited. The eyes were divided into two groups: A as a control (16 eyes), B treated with LRRT (17 eyes). Each patient performed a base-line and 6 months follow-up, complete eye examination including BCVA (logMAR), near visus (pt), threshold sensitivity (TS) by Maia microperimetry (dB) and fundus examination. The tenets of the Declaration of Helsinki were observed.

Results : After 6 months, the mean BCVA in group A changed from 0.720 to 0.698 logMAR (+3.10% - P> 0.5), while group B from 0.638 to 0.632 logMAR (+0.95% - P> 0.5). Mean near visus in group A changed from 25,38 to 25 pts (+1.50% - P> 0.5), while in B from 25,53 to 18,76 pts (+25.52% - P> 0.5). Mean TS in group A changed from 6.27 to 6.59 dB (+6.16% - P> 0.5) while in B from 7.37 to 9,09 dB (+23.34% - P> 0.5). In all eyes near visus was achieved with mean magnification of 3X.

Conclusions : This study shows that the LRRT may improve visual performance in visually impaired patients. Further studies are encourage to determine if biological rehabilitation is possible with cell-based therapy as retinal neuroenhancement.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Mean near visus in group A changed from 25,38 to 25 pts (+1.50%), while in B from 25,53 to 18,76 pts (+25.52%).

Mean near visus in group A changed from 25,38 to 25 pts (+1.50%), while in B from 25,53 to 18,76 pts (+25.52%).

 

Mean TS in group A changed from 6.27 to 6.59 dB (+6.16%), while in B from 7.37 to 9,09 dB (+23.34%).

Mean TS in group A changed from 6.27 to 6.59 dB (+6.16%), while in B from 7.37 to 9,09 dB (+23.34%).

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