June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Oxygen saturation of the retinal vessels may differ between primary open-angle glaucoma and normal-tension glaucoma
Author Affiliations & Notes
  • Kazuyuki Hirooka
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Takeru Shimazaki
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Yuki Nakano
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Eri Nitta
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Kaori Ukegawa
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Akitaka Tsujikawa
    Ophthalmology, Kagawa Univ Faculty of Medicine, Kita-gun, Japan
  • Footnotes
    Commercial Relationships   Kazuyuki Hirooka, None; Takeru Shimazaki, None; Yuki Nakano, None; Eri Nitta, None; Kaori Ukegawa, None; Akitaka Tsujikawa, None
  • Footnotes
    Support  Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (26462689).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 735. doi:
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      Kazuyuki Hirooka, Takeru Shimazaki, Yuki Nakano, Eri Nitta, Kaori Ukegawa, Akitaka Tsujikawa; Oxygen saturation of the retinal vessels may differ between primary open-angle glaucoma and normal-tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2017;58(8):735.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate if there are differences in the retinal oxygen saturation between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients.

Methods : This study enrolled POAG and NTG patients exhibiting differences between the upper and lower total deviation (TD) that were either more than 10 or less than 5 dB. Retinal oxygen saturation measurements in these glaucoma patients were performed by a noninvasive spectrophotometric retinal oximeter. A Student’s t-test was used for the statistical analysis.

Results : Evaluations of the worse and better hemifields in the POAG patients who exhibited differences in the upper and lower hemifield TD that were less than 5 dB (n = 25) showed that there were no statistically significant differences for the retinal venous saturation of oxygen (SaO2) in the venous vessels. However, there was a higher mean SaO2 in the worse (57.0 ± 7.5%) versus the better (54.3 ± 7.0%) hemifield in the NTG patients (n = 22; P = 0.007). Evaluations of the patients with more than a 10 dB difference in the upper and lower hemifield TD showed there were statistically significant differences for the retinal venous SaO2 in the venous vessels between the POAG (n = 19) and the NTG (n = 26) patients.

Conclusions : POAG and NTG patients exhibited a difference in the oxygen saturation of the retinal vessels, which may indicate the existence of a different pathology for POAG and NTG.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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