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Kazuyuki Hirooka, Takeru Shimazaki, Yuki Nakano, Eri Nitta, Kaori Ukegawa, Akitaka Tsujikawa; Oxygen saturation of the retinal vessels may differ between primary open-angle glaucoma and normal-tension glaucoma. Invest. Ophthalmol. Vis. Sci. 2017;58(8):735.
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To investigate if there are differences in the retinal oxygen saturation between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients.
This study enrolled POAG and NTG patients exhibiting differences between the upper and lower total deviation (TD) that were either more than 10 or less than 5 dB. Retinal oxygen saturation measurements in these glaucoma patients were performed by a noninvasive spectrophotometric retinal oximeter. A Student’s t-test was used for the statistical analysis.
Evaluations of the worse and better hemifields in the POAG patients who exhibited differences in the upper and lower hemifield TD that were less than 5 dB (n = 25) showed that there were no statistically significant differences for the retinal venous saturation of oxygen (SaO2) in the venous vessels. However, there was a higher mean SaO2 in the worse (57.0 ± 7.5%) versus the better (54.3 ± 7.0%) hemifield in the NTG patients (n = 22; P = 0.007). Evaluations of the patients with more than a 10 dB difference in the upper and lower hemifield TD showed there were statistically significant differences for the retinal venous SaO2 in the venous vessels between the POAG (n = 19) and the NTG (n = 26) patients.
POAG and NTG patients exhibited a difference in the oxygen saturation of the retinal vessels, which may indicate the existence of a different pathology for POAG and NTG.
This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.
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