June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
To compare the Optical Coherence Tomography (OCT) Parameters in Nepalese Children with Anisometropic Amblyopia, and establish its Relationship with Refractive Error.
Author Affiliations & Notes
  • Raman Prasad Sah
    School of Optometry, Indiana University, Bloomington, Indiana, United States
    Department of Ophthalmology, B.P. Koirala Lions Centre for Ophthalmic Studies, Kathmandu, Nepal
  • Jyoti Baba Shrestha
    Department of Ophthalmology, B.P. Koirala Lions Centre for Ophthalmic Studies, Kathmandu, Nepal
  • Ananda Kumar Sharma
    Department of Ophthalmology, B.P. Koirala Lions Centre for Ophthalmic Studies, Kathmandu, Nepal
  • Footnotes
    Commercial Relationships   Raman Prasad Sah, None; Jyoti Baba Shrestha, None; Ananda Kumar Sharma, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2351. doi:
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      Raman Prasad Sah, Jyoti Baba Shrestha, Ananda Kumar Sharma; To compare the Optical Coherence Tomography (OCT) Parameters in Nepalese Children with Anisometropic Amblyopia, and establish its Relationship with Refractive Error.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2351.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Till date, there are several studies which compare RNFL and macular thickness among amblyopic and normal eyes and the literature have shown varied results. We aimed to compare the Optical Coherence Tomography (OCT) Parameters in Nepalese Children with Anisometropic Amblyopia, compare our findings with that of other studies and establish its Relationship with Refractive Error.

Methods : A total of 115 children (69 males and 46 females) diagnosed with anisometropic amblyopia (either unilateral or bilateral) were enrolled in the study. All children were evaluated for RNFL thickness, macular thickness and macular volume by SD-OCT in amblyopic and fellow eyes for comparison. The amblyopic group was then separated into two groups: Unilateral Amblyopia and Bilateral Amblyopia groups. The mean RNFL and macular parameters were then compared within these groups and with the Normal Control group using ANOVA. The OCT parameters of the amblyopic eyes were further correlated with the Spherical equivalent refractive error using Pearson correlation coefficient.

Results : The mean age of the amblyopic children was 11.4± 3.15 years and of the control group was 12.33± 3.24 years. The mean RNFL thickness, macular thickness and macular volume of the amblyopic eyes were slightly thicker in comparison with normal control eyes except for the RNFL thickness in the temporal quadrant where it was slightly thinner. The global RNFL thickness, mean macular thickness and the mean macular volume were 104.20 ± 23.12 µm, 266.39± 42.12µm and 8.54± 0.80 mm3 respectively in amblyopic eyes and 101.61±18.22 µm, 260.30±29.41 µm and 8.51±.87 mm3 in control eyes. The results were however statistically not significant. The RNFL parameters, the macular thickness and volume all were positively correlated with the spherical equivalent refractive error in the amblyopic eyes with statistically significant values.

Conclusions : Amblyopia is not associated with a change in RNFL thickness, macular thickness or macular volume in Unilateral or Bilateral amblyopia. These OCT parameters were seen to positively correlate with the mean spherical equivalent refractive error in amblyopic eyes.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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