June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Factors Influencing OCT Peripapillary Choroidal Thickness (ppCT) in a Normal Population: A Multi-Center Study
Author Affiliations & Notes
  • Hongli Yang
    Optic Nerve Head Research Lab, Devers Eye Institute, Portland, Oregon, United States
  • Haomin Luo
    Optic Nerve Head Research Lab, Devers Eye Institute, Portland, Oregon, United States
    The 2nd Xiangya Hospital of Central South University, Changsha, China
  • Stuart Keith Gardiner
    Devers Eye Institute, Portland, Oregon, United States
  • Christy Hardin
    Optic Nerve Head Research Lab, Devers Eye Institute, Portland, Oregon, United States
  • Glen Sharpe
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Joseph Caprioli
    Glaucoma, Jules Stein Eye Institute, UCLA, Los Angeles, California, United States
  • Shaban Demirel
    Devers Eye Institute, Portland, Oregon, United States
  • Christopher A Girkin
    Ophthalmology, Univ of Alabama at Birmingham, Birmingham, Alabama, United States
  • Jeffrey M Liebmann
    Ophthalmology, Columbia University Medical Center , New York, New York, United States
  • Christian Y Mardin
    Ophthalmology, University Erlangen-Nurnberg, Nuremberg , Bavaria, Germany
  • Harry A Quigley
    Ophthalmology, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, United States
  • Alexander Scheuerle
    Ophthalmology, University of Heidelberg, Heidelberg, Germany
  • Brad Fortune
    Devers Eye Institute, Portland, Oregon, United States
  • Balwantray C Chauhan
    Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Optic Nerve Head Research Lab, Devers Eye Institute, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Hongli Yang, None; Haomin Luo, None; Stuart Gardiner, None; Christy Hardin, None; Glen Sharpe, None; Joseph Caprioli, Heidelberg Engineering (F); Shaban Demirel, Heifelberg Engineering (F); Christopher Girkin, Heidelberg Engineering (F); Jeffrey Liebmann, Alcon Laboratories,Inc (C), Allergan (C), Bausch Lomb (C), Carl Zeiss Meditech (C), FORSIGHT Vision5 (C), Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S), Inotek Pharmaceuticals,Inc (C), National Eye Institute (S), Quark Pharmacueticals (C), Reichert (C), Sustained Nano Systems (C); Christian Mardin, Heidelberg Engineering (F); Harry Quigley, Heidelberg Engineering (F); Alexander Scheuerle, Heidelberg Engineering (F); Brad Fortune, Inotek Pharmaceuticals (C); Balwantray Chauhan, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S); Claude Burgoyne, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S)
  • Footnotes
    Support  NIH R01 Ey021281, Heidelberg Engineering, Alcon Research Institute, Sears Medical Trust, Good Samaritan Devers Eye Institute Foundation
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4020. doi:
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      Hongli Yang, Haomin Luo, Stuart Keith Gardiner, Christy Hardin, Glen Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Jeffrey M Liebmann, Christian Y Mardin, Harry A Quigley, Alexander Scheuerle, Brad Fortune, Balwantray C Chauhan, Claude F Burgoyne; Factors Influencing OCT Peripapillary Choroidal Thickness (ppCT) in a Normal Population: A Multi-Center Study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4020.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify ppCT by OCT at 100, 300, 500, 700, 900 and 1100 ums from the anterior scleral canal opening (ASCO) within 12 clock-hour sectors oriented to the Foveal-Bruch’s Membrane Opening (FoBMO) axis in 1 eye of 362 normal subjects who represent the ethnic composition of the US population.

Methods : Subjects from 8 centers in Canada, Europe and the US and who were normal by ocular and visual field examination underwent OCT enhanced depth imaging (Spectralis) using a 24 radial B-scan pattern centered on the optic nerve head (ONH) and oriented relative to the FoBMO axis. BMO, Bruch’s membrane (BM), ASCO, and the anterior scleral surface (SS) were manually delineated in each B-scan. OCT B-scans from 9 eyes were each delineated by 4 operators and the intra-class correlation coefficients (ICC) were calculated (two-way ANOVA). The effects of age, axial length (AL), ethnicity, gender, sector, ASCO area, distance from ASCO (ASCO distance) and their interactions, were assessed globally and by sector, by ANOVA, and univariate and multiple regression.

Results : The final analysis included 357 subjects (median age 50.3, range 19.8 to 90.3; 156 male, 201 female; 244 European descent (ED), 46 Hispanic, 45 African descent (AD), 19 Asian, 3 Native American), following exclusion of 5 eyes with poor SS visualization (< half B-scans delineated). Inter-operator ICCs ranged from 0.65 to 0.89. Globally, ppCT was thicker as ASCO distance increased, thicker in AD subjects, thinner in eyes with greater age, AL and ASCO area, (all p<0.001), and slightly thinner in females (p=0.05). Among these, Age and AL explained the greatest proportion of variance (Fig. 1). The rate of age-related decline increased with ASCO distance (p<0.001) (Figs. 1-2). By sector, ppCT was thinnest, and also showed the greatest decline with Age, in the inferior temporal sectors (Fig. 2). Sector 7 (Fig. 2), 500 um from the ASCO, and sectors 7 and 8 at all distances ≥ 700 μm, were significantly thinner than sector 12 and demonstrated a significantly higher rate of age-related loss (data not shown).

Conclusions : In normal eyes, OCT ppCT was thinnest within the inferior temporal sectors and thinner closest to the ASCO. Thinner ppCT was also associated with being female, ED, older (age), larger ASCO area, and longer AL. Among these effectors, age had the strongest influence, and its effect was greatest within the inferior temporal sectors.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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