June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Optical Coherence Tomography Angiography (OCTA): Morphological variations in naïve-choroidal neovascularization after intravitreal treatment (IVT) with antiVEGF
Author Affiliations & Notes
  • Simona Altimari
    Ophthalmology, Colleferro Hospital, Roma, Italy
  • Carmine Luciano Vulcano
    Ophthalmology, Crotone Hospital, Crotone, Italy
  • Alessandro Labate
    Ophthalmology, Crotone Hospital, Crotone, Italy
  • Elisabetta Sterbini
    Ophthalmology, Colleferro Hospital, Roma, Italy
  • Marco Giubilei
    Ophthalmology, Colleferro Hospital, Roma, Italy
  • Footnotes
    Commercial Relationships   Simona Altimari, None; Carmine Luciano Vulcano, None; Alessandro Labate, None; Elisabetta Sterbini, None; Marco Giubilei, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1641. doi:
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      Simona Altimari, Carmine Luciano Vulcano, Alessandro Labate, Elisabetta Sterbini, Marco Giubilei; Optical Coherence Tomography Angiography (OCTA): Morphological variations in naïve-choroidal neovascularization after intravitreal treatment (IVT) with antiVEGF. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1641.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe morphological changes in the naïve choroidal neovascularization (CNV) in patients with AMD, after intravitreal treatment with anti-VEGF (IVT), evaluated with OCTA

Methods : Forty-five eyes were evaluated in 37 patients affected by wet AMD and treated with intravitreal antiVEGF. The morphological characteristics of CNV were assessed by OCT XR Avanti –Optovue before, and 1, 2 and 3 months after injection

Results : Morphological changes of CNV were already observed after the first month and continued to be observed in subsequent months. Major variations concern the reduction of the area of the lesion; and the serious loss of peripheral capillaries with branching vascular plot that constantly increases after each IVT. In 14 patients the appearance of a feeder trunk was observed even after the first injection. In three eyes that have not been subjected to the third injection, we immediately observed a new increase in capillary density.

Conclusions : The OCTA allows us to obtain useful morphological information about the significant variations faced by CNV after treatment with antiVEGF IVT, as well as being a very useful and convenient method of non-invasive investigation

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Variation AOCT of CNV: CNV at T0, T1 CNV one month later but without IVT therpy, T2 after the first IVT, T3 after the second IVT, T4 three months after the second IVT

Variation AOCT of CNV: CNV at T0, T1 CNV one month later but without IVT therpy, T2 after the first IVT, T3 after the second IVT, T4 three months after the second IVT

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