June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Photoreceptor cell injury detected with SD-OCT and fundus autofluorescence in the initial stage of Vogt-Koyanagi-Harada disease
Author Affiliations & Notes
  • Ruilin Zhu
    Department of Ophthalmology, Peking University First Hospital, Beijing, China
    Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China
  • Jing Zhang
    Department of Ophthalmology, Peking University First Hospital, Beijing, China
    Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China
  • Liu Yang
    Department of Ophthalmology, Peking University First Hospital, Beijing, China
    Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China
  • Footnotes
    Commercial Relationships   Ruilin Zhu, None; Jing Zhang, None; Liu Yang, None
  • Footnotes
    Support  National Nature Science Foundation of China 81470650,81670841
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1877. doi:
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    • Get Citation

      Ruilin Zhu, Jing Zhang, Liu Yang; Photoreceptor cell injury detected with SD-OCT and fundus autofluorescence in the initial stage of Vogt-Koyanagi-Harada disease. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1877.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Photoreceptor injury was reported in experimental Vogt-Koyanagi-Harada (VKH) animal model as well as in patients. In this study, we aimed to demonstrate photoreceptor cell injury using spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) in VKH disease.

Methods : Thirty-four eyes of 17 patients diagnosed with VKH disease that was followed up from the initial stage to the convalescent stage were reviewed. All the patients underwent SD-OCT and FAF tests, along with ophthalmological examination at the follow-ups.

Results : In the initial stage of VKH disease, seventeen (50%) eyes of the patients had hyperautofluerescence around the macular and retinal pigment epithelium undulation. In the convalescent stage of VKH disease, the SD-OCT scans revealed the outer nuclear layer attenuation, interruption of myoid zone, ellipsoid zone and outer segments of photoreceptors in convalescent phase, along with suspect interdigitation zone and RPE/Bruch's complex injury. FAF showed the peri-macular hyperfluorescence area persistent existed in the convalescent stage of the disease. The microstructure abnormality of outer retina observed in SD-OCT scans was corresponded to the peri-macular hyperfluorescence in FAF in the initial stage.

Conclusions : The photoreceptor injuries in VKH disease started at the first beginning of the disease and persisted until the convalescent phase of VKH. SD-OCT scan and FAF are effective and noninvasive tools for evaluating photoreceptor cell damage in an early phase in VKH disease. The comprehensive analysis of SD-OCT and FAF could provide us more useful information of VKH disease.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

FAF images of a VKH disease patient in acute phase (top left, top right) and convalescent phase (bottom left, bottom right). In acute phase, FAF showed hypofluorescence in retinal detached region with hyperfluorescence around at the acute phase (top left, top right). In the convalescent phase, the peri-macular hyperfluorescence area persistent existed (bottom left, bottom right).

FAF images of a VKH disease patient in acute phase (top left, top right) and convalescent phase (bottom left, bottom right). In acute phase, FAF showed hypofluorescence in retinal detached region with hyperfluorescence around at the acute phase (top left, top right). In the convalescent phase, the peri-macular hyperfluorescence area persistent existed (bottom left, bottom right).

 

The combination of autofluorescence photography and OCT scan in convalescent stage of a VKH patient. Peri-macular hyperfluorescence in FAF corresponded to the abnormality in OCT scan which showed the thinner of ONL, interruption of myoid zone, ellipsoid zone, the outer segments of photoreceptor and injury of the interdigitation zone and RPE/Bruch's complex.

The combination of autofluorescence photography and OCT scan in convalescent stage of a VKH patient. Peri-macular hyperfluorescence in FAF corresponded to the abnormality in OCT scan which showed the thinner of ONL, interruption of myoid zone, ellipsoid zone, the outer segments of photoreceptor and injury of the interdigitation zone and RPE/Bruch's complex.

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