June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Prevalence of Outer Retinal Atrophy in Idiopathic Multifocal Choroiditis Associated with Persistent Fundus Hyperautofluorescence
Author Affiliations & Notes
  • Talia R Kaden
    Ophthalmology, New York University, New York, New York, United States
  • Rosa Dolz-Marco
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
    The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, New York, New York, United States
  • Chandra Bala
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
    Centre for Ophthalmology and Visual Sciences, University of Western Australia, Perth, Western Australia, Australia
  • K Bailey Freund
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
    The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, New York, New York, United States
  • Lawrence A. Yannuzzi
    Vitreous Retina Macula Consultants of New York, New York, New York, United States
    The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, New York, New York, United States
  • Footnotes
    Commercial Relationships   Talia Kaden, None; Rosa Dolz-Marco, None; Chandra Bala, None; K Bailey Freund, Bayer HealthCare (R), Genentech (R), Heidelberg Engineering (R), Optos (R), Optovue (R); Lawrence A. Yannuzzi, Genentech (R)
  • Footnotes
    Support  The LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY AND The Macular Foundation, Inc., New York, NY
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1883. doi:
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      Talia R Kaden, Rosa Dolz-Marco, Chandra Bala, K Bailey Freund, Lawrence A. Yannuzzi; Prevalence of Outer Retinal Atrophy in Idiopathic Multifocal Choroiditis Associated with Persistent Fundus Hyperautofluorescence. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1883.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the prevalence and anatomic correlates for an uncommon variant of idiopathic multifocal choroiditis (MFC) characterized by regions of hyperautofluorescence showing minimal change over an extended follow-up.

Methods : Retrospective review of MFC patients from a single retina practice. Fluorescein angiography, indocyanine green angiography, optical coherence tomography, fundus autofluorescence and ultra-widefield imaging data were reviewed. The spatial and temporal characteristics of outer retinal and chorioretinal lesions were evaluated.

Results : Fifty-five eyes from 34 patients with a mean follow-up period of 4.6 years were analyzed. All eyes demonstrated pigmented, punched-out chorioretinal scars, with additional findings including peripheral curvilinear scars, vitritis and choroidal neovascularization. In addition, 5 eyes (9.1%) demonstrated a persistent fundus autofluorescence pattern characterized by regions of fundus hyperautofluorescence occurring in the posterior pole and/or periphery. In these 5 eyes, both visual acuity and the intensity and size of these hyperautofluorescent showed minimal change over an extended follow-up. Correlation of multimodal imaging data showed that the regions of hyperautofluorescence correlated with structural changes in the outer retina, without observable alterations at the level of the choroid or retinal pigment epithelium.

Conclusions : This study reports the prevalence and multimodal imaging characteristics of a rare variant of idiopathic MFC. These findings expand our understanding of the range clinical features occurring in this disorder.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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