June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Evaluation of macular and papillary morphometric parameters in amblyopic eyes
Author Affiliations & Notes
  • Anna Maffia
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Alice Chandra Verticchio Vercellin
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Rosanna Guagliano
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Donatella Barillà
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Carmine Tinelli
    Clinical Epidemiology and Biometric Unit, IRCCS, Policlinico San Matteo, Pavia, Pavia, Italy
  • Paolo Emilio Bianchi
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Giovanni Milano
    Ophthalmology, University Eye Clinic, IRCCS Policlinico San Matteo, Pavia , Pavia, Italy
  • Footnotes
    Commercial Relationships   Anna Maffia, None; Alice Chandra Verticchio Vercellin, None; Rosanna Guagliano, None; Donatella Barillà, None; Carmine Tinelli, None; Paolo Emilio Bianchi, None; Giovanni Milano, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2353. doi:
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      Anna Maffia, Alice Chandra Verticchio Vercellin, Rosanna Guagliano, Donatella Barillà, Carmine Tinelli, Paolo Emilio Bianchi, Giovanni Milano; Evaluation of macular and papillary morphometric parameters in amblyopic eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2353.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the macular and papillary parameters by spectral domain optical coherence tomography (SD-OCT) in children affected by amblyopia.

Methods : 234 eyes of 117 children (102 male; mean age: 8,89 years) were divided into 4 groups: group 0 (162 healthy eyes of 81 subjects with both eyes without amblyopia); group 1 (32 healthy eyes of 32 subjects with monolateral amblyopia); group 2 (32 amblyopic eyes of 32 subjects with monolateral amblyopia), and group 3 (8 amblyopic eyes of 4 subjects with bilateral amblyopia). All the subjects were assessed for optic nerve head (ONH) parameters, retinal nerve fiber layer (RNFL) thickness, ganglion cell complex (GCC) thickness, macular thickness at 3 and 5 mm from the fovea, and retina map and ONH scan quality index (SQI) by SD OCT iVue, Optovue (Fremont, CA; Optovue, Inc.). Two-sided p values <0.05 were considered statistically significant. Stata 13 (Stata Corporation, College Station, 2014, Texas, USA) was used for all computations.

Results : The rim area was 2.08 mm2 (Standard deviation, SD: 0.49) in group 0 and 1.76 mm2 (SD: 0.68) in group 2; the disc area was 2.43 mm2 (SD: 0.45) in group 0 and 2.02 mm2 (SD: 0.71) in group 2; the central macular thickness was 250.99 µm (SD:19.74) in group 0 and 267.16 µm (SD: 23.52) in group 2; the SQI ONH was 62.82 (SD: 13.15) in group 0, 51.26 (SD: 15.55) in group 2, 48.29 (SD: 14.37) in group 3; the SQI retina map was 63.34 (SD: 10.34) in group 0 and 57.34 (SD: 9.84) in group 2, leading to a statistically significant difference between the aforementioned groups (p<0.005). All other parameters (average RNFL thickness, average superior RNFL, average inferior RNFL, cup/disc area ratio, cup/disc vertical ratio, cup/disc horizontal ratio, cup volume, superior, inferior, nasal and temporal macular thickness at 3 and 5 mm from the fovea and GCC average thickness total, superior, and inferior) did not differ between the groups analysed (p>0,005).

Conclusions : Amblyopia affects morphometric parameters of the ONH and of the macula and the quality of the images assessed by SD OCT.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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