June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Choroidal thickness and myopia in relation to physical activity during childhood
Author Affiliations & Notes
  • Kristian Lundberg
    Department of Ophthalmology, Odense University Hospital, Odense C, Denmark
    Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  • Nina Jakobsen
    Department of Ophthalmology, Rigshospitalet-Glostrup University Hospital, Copenhagen, Denmark
  • Anders Vestergaard
    Department of Ophthalmology, Odense University Hospital, Odense C, Denmark
    Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  • Ernst Goldschmidt
    Danish Institute for Myopia Research, Vedbæk, Denmark
  • Tunde Peto
    Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
    Queen’s University Belfast, Belfast, United Kingdom
  • Niels Wedderkopp
    Research in Childhood Health, Institute for Regional Heath Research, University of Southern Denmark, Odense, Denmark
    Sport medicine Clinic, the Orthopedic Department, Hospital of Middelfart, Institute of Regional Health Services Research, University of Southern Denmark, Middelfart, Denmark
  • Michael Larsen
    Department of Ophthalmology, Rigshospitalet-Glostrup University Hospital, Copenhagen, Denmark
  • Jakob Grauslund
    Department of Ophthalmology, Odense University Hospital, Odense C, Denmark
    Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
  • Footnotes
    Commercial Relationships   Kristian Lundberg, None; Nina Jakobsen, None; Anders Vestergaard, None; Ernst Goldschmidt, None; Tunde Peto, None; Niels Wedderkopp, None; Michael Larsen, None; Jakob Grauslund, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2376. doi:
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      Kristian Lundberg, Nina Jakobsen, Anders Vestergaard, Ernst Goldschmidt, Tunde Peto, Niels Wedderkopp, Michael Larsen, Jakob Grauslund; Choroidal thickness and myopia in relation to physical activity during childhood. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2376.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Decreasing physical activity (PA) has been suggested to be a driving force behind the rapid increase of myopia. The possible protective effects of PA might be through increased blood flow and subsequent change in thickness of the choroid. The purpose of this study was to correlate PA, myopia, and choroidal thickness (CT).

Methods : A prospective study of 307 children from the CHAMPS-study Denmark. Objective data from GT3X accelerometer (ActiGraph, USA) worn at 4 periods between 2009 and 2015 were used to determine amount of PA. Intensity was estimated as counts/minutes, and cut off-points were defined at four levels; sedentary (SED), light (L), moderate (M) and vigorous (V). Eye examinations were performed in 2015 and included autorefraction in cyclopegia (Tonoref II, Nidek, Japan), axial length (AL) by biometri (Lenstar 900, Haag Streit, Switzerland) and fovea-centered radial scans of 4 sections by enhanced depth imaging optical coherence tomography (EDI-OCT) (Heidelberg Spectralis, Germany). By a validated semi-automated method we measured the CT at 17 targets per eye representing different choroidal locations (subfoveal, 1 and 3 millimeter in each direction of fovea). Linear regression and slope coefficients of repeated PA were performed to evaluate the association between PA, myopia and CT.

Results : Mean age at follow-up was 15.4±0.7 years (range 14.3 to 17.5) and 52.4% were boys. The mean spherical equivalent (SE) was 0.3±1.5 diopters (cycloplegia) and 17.9% were myopic (SE -0.5 diopters). The mean AL was 23.5±0.9 mm. The mean subfoveal CT was 369±87 µm. The mean CT for myopic vs. non-myopic eyes was 259±65 µm vs. 354±71 µm (macula), 313±77 µm vs. 382±84 µm (fovea), 306±71 µm vs. 368±80 µm (1 mm zone) and 267±52 µm vs. 312±59 µm (3 mm zone), respectively. All CT measurements were thinner in myopic eyes (p<0.0001) and in boys (p<0.05). By linear regression there were no associations between PA and SE, AL or any CT measurements. There was no association between accumulated PA and the overall CT for SED, L, M and V PA (2.31 µm/% (p=0.22), -3.99 µm/% (p=0.15), -5.43 µm/% (p=0.57) and -0.53 µm/% (p=0.95), respectively).

Conclusions : We found no association between physical activity and the choroidal thickness, axial length or refractive error. However, the choroid was thinner in myopic eyes and in boys. The role of choroidal thickness on the development of refraction should be investigated in prospective studies

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

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