June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Pre-operative Prediction of Post-cataract Surgery IOL Position Using Anterior Chamber Depth and Lens Thickness Determined with Extended-depth OCT
Author Affiliations & Notes
  • Yu-Cherng Chang
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Florence Cabot
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Siobhan Williams
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Giovanni Gregori
    Quantitative Imaging Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Marco Ruggeri
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Sonia H Yoo
    Anne Bates Leach Eye Hospital, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Jean-Marie A Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Brien Holden Vision Institute and Vision Cooperative Research Centre, Sydney, New South Wales, Australia
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida, United States
  • Footnotes
    Commercial Relationships   Yu-Cherng Chang, None; Florence Cabot, None; Siobhan Williams, None; Giovanni Gregori, None; Marco Ruggeri, US Patent 8,425,037 (P); Sonia Yoo, None; Jean-Marie Parel, US Patent 8,425,037 (P); Fabrice Manns, US Patent 8,425,037 (P)
  • Footnotes
    Support  National Eye Institute Grants 2R01EY14225, P30EY14801 (Center Grant); Florida Lions Eye Bank; Drs KR Olsen and ME Hildebrandt; Drs R Urs and A Furtado; the Henri and Flore Lesieur Foundation (JMP); an unrestricted grant from Research to Prevent Blindness; and the Australian Federal Government Cooperative Research Centre Scheme through the Vision Cooperative Research Centre
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 2717. doi:
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    • Get Citation

      Yu-Cherng Chang, Florence Cabot, Siobhan Williams, Giovanni Gregori, Marco Ruggeri, Sonia H Yoo, Jean-Marie A Parel, Fabrice Manns; Pre-operative Prediction of Post-cataract Surgery IOL Position Using Anterior Chamber Depth and Lens Thickness Determined with Extended-depth OCT. Invest. Ophthalmol. Vis. Sci. 2017;58(8):2717.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the precision of post-cataract surgery IOL position prediction using anterior chamber depth (ACD) and lens thickness (LT) as determined with extended depth Optical Coherence Tomography (OCT)

Methods : Five eyes from four patients (34, 64, 77, and 79 years old) undergoing cataract surgery were imaged before and 1 month after the procedure using a custom-built extended depth OCT system which produces whole eye images ranging in depth from the cornea to retina (Ruggeri et al, Biomed Opt Express 3:1506-1520; 2012) (8.6 frames/s, 400 A-lines/B-scan, 8 µm axial resolution; Figure 1). Pre- and post-operative anterior chamber depth (ACD) and pre-operative lens thickness (LT) were determined along the A-line passing through the corneal apex. A linear regression was performed to model the relationship between pre-operative ACD and LT, and post-operative IOL position (post-operative ACD) according to the formula: post-operative ACD = pre-operative ACD + C x LT, where C is an empirically-derived constant (T Olsen and Hoffmann, J Cat Ref Surg 40:764-773; 2014). The prediction error was quantified by comparing the predicted and measured post-operative IOL position.

Results : Average pre-operative ACD, LT and post-operative ACD were 2.76 ± 0.59, 4.68 ± 0.44, and 4.24 ± 0.55 mm, respectively. The value of the C-constant derived from the five eyes was 0.315 ± 0.012. The residual error of the linear regression was less than 85 µm for all eyes (average of 45.4 ± 27.8 µm; Figure 2) corresponding to a refractive error of less than 0.2 D in a hyperopic eye.

Conclusions : Pre-operative ACD and LT derived from extended-depth OCT can be used with the C-constant method to predict post-cataract surgery IOL position.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure 1: Example pre- (left) and post-operative (right) OCT images from the 79 year old subject.

Figure 1: Example pre- (left) and post-operative (right) OCT images from the 79 year old subject.

 

Figure 2: Scatter plot of measured post-operative IOL position (post-operative measured ACD) and prediction error for each eye.

Figure 2: Scatter plot of measured post-operative IOL position (post-operative measured ACD) and prediction error for each eye.

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