June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Inter-scan repeatability of drusen and geographic atrophy measurements using spectral domain optical coherence tomography in eyes with Age related macular degeneration
Author Affiliations & Notes
  • Jyotsna Maram
    Ophthalmology , Doheny eye Institute , Alhambra, California, United States
  • Muneeswar Gupta Nittala
    Ophthalmology , Doheny eye Institute , Alhambra, California, United States
  • Amir H Hariri
    Ophthalmology , Doheny eye Institute , Alhambra, California, United States
  • Srinivas R Sadda
    Ophthalmology , Doheny eye Institute , Alhambra, California, United States
  • Footnotes
    Commercial Relationships   Jyotsna Maram, None; Muneeswar Nittala, None; Amir Hariri, None; Srinivas Sadda, allergan (F), allergan (C), carl zeiss meditec (F), genentech (F), genentech (C), Iconic (C), novartis (C), optos (F), optos (C), thrombogenics (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 31. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Jyotsna Maram, Muneeswar Gupta Nittala, Amir H Hariri, Srinivas R Sadda; Inter-scan repeatability of drusen and geographic atrophy measurements using spectral domain optical coherence tomography in eyes with Age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2017;58(8):31.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Optical coherence tomography (OCT)-derived geographic atrophy (GA) area has been proposed as a potential outcome measure in clinical trials, and OCT drusen volume in the central 3mm has been identified to be an important risk factor for late AMD. The purpose of this analysis is to evaluate the repeatability of drusen and GA measurements with two different OCT scan protocols in eyes with dry age-related macular degeneration (AMD)

Methods : Subjects with dry AMD who underwent SD-OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Inc., Dublin, CA) imaging using two different scan protocols (two acquisitions of 512x128 and single acquisition of 200x200) at the Doheny Eye Centers-UCLA were included in this IRB-approved, study. Drusen area and volume (in 3mm and 5 mm circles centered on the fovea) and geographic atrophy area (in a central 5 mm circle) were measured using an FDA-cleared automated algorithm (Cirrus OCT Advanced RPE analysis). Inter-scan repeatability for drusen and GA measurements were analyzed using Intra class correlation (ICC) and student t-test.

Results : Forty eyes of 20 AMD subjects were included. There was no significant difference in GA area between the two consecutive 512x128 volume scans (8.09 ± 4.25 vs. 7.99 ± 4.25, p = 0.47) with excellent agreement (ICC=0.98; 95% CI: 0.979 – 0.994). Similarly, drusen area (p = 0.38) and volume (p= 0.70) measurements also showed no statistically significant difference between the two 512x128 scans. There was, however, a significant difference for drusen volume in the central 3 mm between the 512x128 and 200x200 protocols (0.02 ± 0.03 mm3 vs. 0.015 ± 0.022 mm3, p = 0.02) (Table 1) – though drusen volume in the central 5mm and drusen area did not differ significantly between protocols. There was no statistically significant difference in GA area between the 512x128 and 200x200 protocols (7.99 ± 4.25 vs. 8.71 ± 4.83, p = 0.11) with excellent correlation (ICC=0.97; 95% CI: 0.948 – 0.988).

Conclusions : While it appears that both OCT macular cube protocols (512x128 and 200x200) yield somewhat similar and highly correlated measurements for GA, they do appear to differ with regards to drusen volume in the central 3mm. These differences will need to be considered when designing studies utilizing these protocols.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×