June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Initial clinical experience with a novel high-speed ultra-compact handheld swept source optical coherence tomography imaging system to evaluate retinal microanatomy in adults, children and infants
Author Affiliations & Notes
  • Du Tran-Viet
    Duke University Eye Center, Durham, North Carolina, United States
  • Shwetha Mangalesh
    Duke University Eye Center, Durham, North Carolina, United States
  • Francesco LaRocca
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Derek Nankivil
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
    Johnson & Johnson Vision Care Inc., Jacksonville, Florida, United States
  • Christian Viehland
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Brenton Keller
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Alexandria Dandridge
    Duke University Eye Center, Durham, North Carolina, United States
  • Sharon F. Freedman
    Duke University Eye Center, Durham, North Carolina, United States
  • Joseph A Izatt
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Cynthia A Toth
    Duke University Eye Center, Durham, North Carolina, United States
    Biomedical Engineering, Duke University, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Du Tran-Viet, None; Shwetha Mangalesh, None; Francesco LaRocca, None; Derek Nankivil, None; Christian Viehland, None; Brenton Keller, None; Alexandria Dandridge, None; Sharon Freedman, None; Joseph Izatt, Leica Microsystems (P), Leica Microsystems (R); Cynthia Toth, Alcon Laboratories (P), Genentech (F)
  • Footnotes
    Support  NIH Grant RO1EY025009-01A1
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3121. doi:
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      Du Tran-Viet, Shwetha Mangalesh, Francesco LaRocca, Derek Nankivil, Christian Viehland, Brenton Keller, Alexandria Dandridge, Sharon F. Freedman, Joseph A Izatt, Cynthia A Toth; Initial clinical experience with a novel high-speed ultra-compact handheld swept source optical coherence tomography imaging system to evaluate retinal microanatomy in adults, children and infants. Invest. Ophthalmol. Vis. Sci. 2017;58(8):3121.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate application of high-speed, handheld, ultra-compact, swept-source optical coherence tomography (SSOCT) imaging system on adults, children and infants in the intensive care nursery (ICN). We hypothesize that SSOCT imaging and processing will reveal distinct patterns of abnormalities in retinal structures responsible for sensory input along the visual pathway in preterm infants.

Methods : Under the Duke Institutional review board approved protocol, we obtained images using an investigational research SSOCT device developed by Duke Biomedical Engineers. This device utilized a 1050 nm swept-frequency laser, custom optics and mechanics, and a 2D microelectromechanical systems scanner, with a weight of 211g. Healthy adult volunteers (non-dilated pupils) and children undergoing examination under anesthesia (EUA) were imaged prior to bedside imaging in preterm infants. We attempted to capture fovea, optic nerve and temporal periphery at all imaging sessions.

Results : Four (8 eyes) healthy adult volunteers, 4 (8 eyes) children (15 months-8 years) undergoing EUA and 3 (6 eyes) preterm infants (28-31 weeks gestational age) were enrolled. We obtained multiple OCT volumes with an image acquisition time of one volume per second. We acquired good quality fovea and optic nerve scans from all participants. Microanatomy of retinoschisis and optic nerve hypoplasia, were identified on OCT during EUA. In the ICN, bedside imaging was conducted during multiple visits at the time of preterm infant’s examination for retinopathy of prematurity (ROP). We were able to follow and monitor the temporal periphery weekly as the ROP progressed from Stage 2 to 3. SSOCT imaging revealed vessel elevation, worsening severity of neovascular buds and complex at the vascular-avascular junction. With montage overlay, temporal retinal vascular development could be tracked.

Conclusions : A novel SSOCT device allows for faster image acquisition in infants and adults with and without pupil dilation. This innovation can simplify bedside imaging in infants and provide useful clinical correlation in preterm infants with ROP and revolutionize the management and prediction of future visual outcome in these infants.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Swept Source Optical Coherence Tomography imaging on adult volunteer and images of the retina on a 40 week old infant.

Swept Source Optical Coherence Tomography imaging on adult volunteer and images of the retina on a 40 week old infant.

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