June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Analysis of retinal nerve fiber layer microvasculature in non-glaucomatous optic neuropathy using optical coherence tomography angiography (OCTA)
Author Affiliations & Notes
  • Arjun Tudi Reddy
    USC Roski Eye Institute , Los Angeles , California, United States
    Keck School of Medicine of the University of Southern California, Los Angeles , California, United States
  • Vivek Patel
    USC Roski Eye Institute , Los Angeles , California, United States
    Keck School of Medicine of the University of Southern California, Los Angeles , California, United States
  • Beau Sylvester
    USC Roski Eye Institute , Los Angeles , California, United States
    University of Southern California, Los Angeles , California, United States
  • Zhongdi Chu
    University of Washington, Seattle , Washington, United States
  • Amir Kashani
    USC Roski Eye Institute , Los Angeles , California, United States
    Keck School of Medicine of the University of Southern California, Los Angeles , California, United States
  • Ruikang K Wang
    University of Washington, Seattle , Washington, United States
  • Grace Marie Richter
    USC Roski Eye Institute , Los Angeles , California, United States
    Keck School of Medicine of the University of Southern California, Los Angeles , California, United States
  • Footnotes
    Commercial Relationships   Arjun Reddy, Carl Zeiss Meditec (F); Vivek Patel, Carl Zeiss Meditec (F); Beau Sylvester, Carl Zeiss Meditec (F); Zhongdi Chu, None; Amir Kashani, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (R); Ruikang Wang, Carl Zeiss Meditec (F), Carl Zeiss Meditec (C), Carl Zeiss Meditec (R), Carl Zeiss Meditec (P); Grace Richter, Carl Zeiss Meditec (F)
  • Footnotes
    Support  1) Unrestricted institutional grant from Research to Prevent Blindness (USC Roski Eye Institute); 2) American Glaucoma Society Mentoring for Advancement of Physician Scientists (GMR)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 3867. doi:
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    • Get Citation

      Arjun Tudi Reddy, Vivek Patel, Beau Sylvester, Zhongdi Chu, Amir Kashani, Ruikang K Wang, Grace Marie Richter; Analysis of retinal nerve fiber layer microvasculature in non-glaucomatous optic neuropathy using optical coherence tomography angiography (OCTA). Invest. Ophthalmol. Vis. Sci. 2017;58(8):3867.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To demonstrate the degree of correlation between retinal microvasculature parameters and retinal nerve fiber layer (RNFL) thickness in the peripapillary region in non-glaucomatous optic neuropathy (NGON), using optical coherence tomography angiography (OCTA) and optical coherence tomography (OCT) respectively.

Methods : 6x6 mm2 images of the optic nerve head were obtained on patients with non-glaucomatous optic neuropathies and normal patients using the Angioplex spectral-domain OCTA and optic nerve scans for RNFL thickness were collected using the Cirrus 5000 SD-OCT (Carl Zeiss Meditec, Dublin, CA). Scans of signal strength of ≥6 (out of 10) were selected for the study. Semi-automatic segmentation of the volumetric OCTA data was performed and en face projections of vasculature at precise retinal layers were produced using prototype software. En face vasculature images of the RNFL layer were quantified, and were used to measure three OCTA perfusion parameters globally and in specific sectors (quadrants and clock-hour sectors). Vessel area density (VAD) and vessel skeleton density (VSD) were the parameters used to assess microvascular density, while vessel complexity index (VCI) was used to assess vessel morphology. Correlations between RNFL thickness and microvascular density were performed using Spearman’s rank correlation. Perfusion parameters of normal and NGON patients were compared using the Mann-Whitney U test.

Results : 25 NGON eyes and 10 normal eyes were assessed. NGON eyes had significantly lower VAD, VSD, and VCI global compared to normal eyes. Among NGON eyes, stastically significant positive correlations were found between both VSD and VAD perfusion parameters with RNFL thickness in all retinal quadrants. In addition, the majority of retinal clock-hour segments showed positive correlations between VSD and VAD perfusion parameters and RNFL. Finally, there was a positive correlation between VCI and RNFL thickness among the majority of retinal quadrants.

Conclusions : There was reduced peripapillary microvascular perfusion in NGON compared to normal eyes. Among NGON eyes, microvascular perfusion had a strong anatomic correlation with RNFL thickness. SD-OCTA imaging exhibits the ability to detect retinal microvascular changes and may be an important diagnostic modality when utilized in conjunction with OCT imaging.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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