June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Factors Influencing OCT Central Anterior Lamina Cribrosa Surface Depth within a Normal Population: A Multi-Center Study
Author Affiliations & Notes
  • Haomin Luo
    Optic Nerve Head Research Lab, Devers eye Institute, Portland, Oregon, United States
    The 2nd Xiangya Hospital of Central South University, Changsha, China
  • Hongli Yang
    Optic Nerve Head Research Lab, Devers eye Institute, Portland, Oregon, United States
  • Stuart Keith Gardiner
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Christy Hardin
    Optic Nerve Head Research Lab, Devers eye Institute, Portland, Oregon, United States
  • Glen Sharpe
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Joseph Caprioli
    Glaucoma, Jules Stein Eye Institute, UCLA, Los Angeles, California, United States
  • Shaban Demirel
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Christopher A Girkin
    Ophthalmology, Univ of Alabama at Birmingham, Birmingham, Alabama, United States
  • Jeffrey M Liebmann
    Ophthalmology, Columbia University Medical Center, New York, New York, United States
  • Christian Y Mardin
    Ophthalmology, University Erlangen-Nurnberg, Nurnberg, Germany
  • Harry A Quigley
    Ophthalmology, Johns Hopkins Wilmer Eye Inst, Baltimore, Maryland, United States
  • Alexander Scheuerle
    Ophthalmology, University of Heidelberg, Heidelberg, Germany
  • Brad Fortune
    Discoveries in Sight Research Labs, Devers Eye Institute, Portland, Oregon, United States
  • Balwantray C Chauhan
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
  • Claude F Burgoyne
    Optic Nerve Head Research Lab, Devers eye Institute, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Haomin Luo, None; Hongli Yang, None; Stuart Gardiner, None; Christy Hardin, None; Glen Sharpe, None; Joseph Caprioli, Heidelberg Engineering (F); Shaban Demirel, None; Christopher Girkin, Heidelberg Engineering (F); Jeffrey Liebmann, Alcon Laboratories,Inc (C), Allergan (C), Carl Zeiss Meditech (C), FORSIGHT (C), Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S), National Eye Institute (S), Quark Pharmacueticals (C), Reichert (C), Sustained Nano Systems (C); Christian Mardin, Heidelberg Engineering (F); Harry Quigley, Heidelberg Engineering (F); Alexander Scheuerle, Heidelberg Engineering (F); Brad Fortune, Inotek Pharmaceuticals (C); Balwantray Chauhan, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S); Claude Burgoyne, Heidelberg Engineering (C), Heidelberg Engineering (F), Heidelberg Engineering (S)
  • Footnotes
    Support  NIH R01 Ey021281, Heidelberg Engineering, Alcon Research Institute, Sears Medical Trust, Good Samaritan Devers Eye Institute Foundation.
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4016. doi:
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      Haomin Luo, Hongli Yang, Stuart Keith Gardiner, Christy Hardin, Glen Sharpe, Joseph Caprioli, Shaban Demirel, Christopher A Girkin, Jeffrey M Liebmann, Christian Y Mardin, Harry A Quigley, Alexander Scheuerle, Brad Fortune, Balwantray C Chauhan, Claude F Burgoyne; Factors Influencing OCT Central Anterior Lamina Cribrosa Surface Depth within a Normal Population: A Multi-Center Study. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4016.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify the effects of age, axial length (AL), ethnicity and gender on OCT anterior lamina cribrosa surface depth (ALCSD) in 1 eye of 362 subjects who represent the ethnic composition of the US population.

Methods : Subjects from 8 centers in Canada, Europe and the US and who were normal by ocular and visual field examination underwent OCT enhanced depth imaging (Spectralis) of the optic nerve head (ONH) using a 24 radial B-scan pattern aligned to the Foveal-Bruch’s Membrane Opening (BMO) axis. BMO, ALCS, anterior scleral canal opening (ASCO), Bruch’s membrane (BM), and the anterior scleral surface (SS) were manually delineated in each B-scan. ALCS visualization was quantified within 72 ASCO subsectors, requiring ≥1 delineated point per subsector. OCT B-scans from 9 eyes were each delineated by 4 operators and the intra-class correlation coefficients (ICC) were calculated. Central (central 24 subsectors) ALCSD was quantified relative to 4 reference planes: BMO, ASCO, BM (1700um from the BMO centroid), and SS (1700um from the ASCO centroid). The effects of age, gender, ethnicity, BMO area, ASCO area and AL on Central ALCSD were assessed by ANOVA and univariate and multiple regression.

Results : Median LC visualization within the central sub-sectors was 89%, (range 69-95%, Fig. 1). Central ALCSD ICCs were ≥0.87 for each reference plane. The final analysis included 339 subjects, (median age 50, range 20-90; 143 male, 196 female; 232 European descent, 43 Hispanic, 43 African descent (AD), 18 Asian, 3 Native American) after exclusion of 23 eyes for poor laminar (18) and scleral (5) visualization. By ANOVA, central ALCSD-BMO was shallower in females (p=0.005) and was shallower in eyes with greater age (p=0.0005), BMO area (p=0.03) and AL (p=0.001) (Fig. 2). Central ALCSD-BM behaved similarly, but was the only parameter influenced by ethnicity, being deeper in AD eyes (p=0.0002). Central ALCSD-ASCO was shallower in females (p=0.04) and was shallower in eyes with greater ASCO area (p=0.0003) and AL (p=0.01). Central ALCSD-SS was influenced by ASCO area (shallower in eyes with greater ASCO area (p=0.007)), and gender (shallower in females (p=0.04)), only.

Conclusions : OCT Central ALCSD is modestly shallower in females and also shallower in eyes with greater age, AL, ASCO area and BMO area, being affected by the fewest of these when measured relative to the ASCO and SS.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

 

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