June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Quantitative Fundus Autofluorescence (qAF) in Normal Phakic and Pseudophakic Patients Using SPECTRALIS® qAF Imaging and Analysis Module
Author Affiliations & Notes
  • Meleha Ahmad
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Nicole Topilow
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Julia Agee
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Samantha Ayoub
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Nathaniel Tracer
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Heather Leisy
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Gabriella Guevara
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Theodore Smith
    Ophthalmology, New York University School of Medicine, New York, New York, United States
  • Footnotes
    Commercial Relationships   Meleha Ahmad, None; Nicole Topilow, None; Julia Agee, None; Samantha Ayoub, None; Nathaniel Tracer, None; Heather Leisy, None; Gabriella Guevara, None; Theodore Smith, None
  • Footnotes
    Support  R01 EY015520
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 4854. doi:
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    • Get Citation

      Meleha Ahmad, Nicole Topilow, Julia Agee, Samantha Ayoub, Nathaniel Tracer, Heather Leisy, Gabriella Guevara, Theodore Smith; Quantitative Fundus Autofluorescence (qAF) in Normal Phakic and Pseudophakic Patients Using SPECTRALIS® qAF Imaging and Analysis Module. Invest. Ophthalmol. Vis. Sci. 2017;58(8):4854.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : qAF imaging is used to track retinal pigment epithelium (RPE) health in the research setting and will soon be available clinically. Knowledge of normal qAF patterns is useful in detecting qAF abnormalities caused by RPE disease. Our purpose was to establish normative data on the investigational SPECTRALIS® qAF Imaging and Analysis Module for younger phakic and older pseudophakic patients.

Methods : We performed qAF imaging on 51 patients (82 eyes) using the SPECTRALIS® qAF Imaging and Analysis Module. We included 32 phakic patients < 50 years old without cataracts and 19 pseudophakic patients > 50 years old with clear posterior capsules. Patients with evidence of retinal abnormalities on dilated fundus exam or macular spectral domain optical coherence tomography were excluded. Analysis was conducted using inbuilt qAF software for the third concentric ring of the “Delori pattern” centered on the fovea to generate qAF-8 values for each eye. In patients with bilateral imaging, qAF-8 was averaged for both eyes to generate a single mean qAF-8 measurement. qAF-8 was plotted against age with linear regressions on all patients and patient groupings of < 50 and > 50 years old.

Results : qAF-8 was positively associated with age in the overall group (correlation coefficient (CC) 0.51, R2 0.05, range 76-243). In addition, qAF-8 was positively associated with age in younger patients (CC 3.03, R2 0.32, range 76-230) and in older patients (CC 1.90, R2 0.09, range 70-243). There was no significant overall difference between average qAF-8 in phakic patients < 50 years and pseudophakic patients > 50 years old (p=0.52).

Conclusions : qAF-8 can be successfully measured in healthy eyes using the SPECTRALIS® qAF Imaging and Analysis Module. qAF-8 values are positively associated with age and show significantly higher variability in pseudophakic patients > 50 years as compared to phakic patients < 50 years old. In pseudophakic patients, however, the SPECTRALIS® qAF Analysis Module appears to underestimate the qAF compared to the expected upward continuation of the values for younger phakic patients. Further exploration of normative qAF values for this new technology is required.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

qAF-8 vs. age for phakic patients < 50 years old (blue line) and pseudophakic patients > 50 years old (red line).

qAF-8 vs. age for phakic patients < 50 years old (blue line) and pseudophakic patients > 50 years old (red line).

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