June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Spectral Domain Optical Coherence Tomography Findings in Tunisian Patients with Multiple Sclerosis
Author Affiliations & Notes
  • Salim Ben Yahia
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Rim Kahloun
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Afef Chebbah
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Imen Ksiaa
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Hajer Ben Amor
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Bechir Jelliti
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Moncef Khairallah
    Ophthalmology, Fattouma Bourguiba Univ Hosp, Monastir, Tunisia
  • Footnotes
    Commercial Relationships   Salim Ben Yahia, None; Rim Kahloun, None; Afef Chebbah, None; Imen Ksiaa, None; Hajer Ben Amor, None; Bechir Jelliti, None; Moncef Khairallah, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5114. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Salim Ben Yahia, Rim Kahloun, Afef Chebbah, Imen Ksiaa, Hajer Ben Amor, Bechir Jelliti, Moncef Khairallah; Spectral Domain Optical Coherence Tomography Findings in Tunisian Patients with Multiple Sclerosis. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5114.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Spectral domain optical coherence tomography (SD-OCT) is a non-invasive tool that may be useful to assess disease severity in patients with multiple sclerosis (MS). The purpose of our study was to assess SD-OCT findings in Tunisian patients with MS.

Methods : Prospective cross-sectional comparative study including 56 patients with MS and 20 healthy age-matched control subjects. Detailed ophthalmic examination and SD-OCT were performed in all patients.

Results : Mean age of our patients was 36.16 +/- 1.5 years (Range, 18-63). Forty-one patients (73.2%) were female. Twenty-nine patients (51.8%) had history of optic neuritis. Optic neuritis was unilateral in 12 patients and bilateral in 17 patients. Mean foveal thickness was 253.33 µm +/- 19.8 in patients with MS and 267.76 µm +/- 10.48 in control group (p <0.01). Mean macular volume was 7.18 mm3 +/- 0.57 in patients with MS and 7.57 mm3 +/- 0.3 in control group (p <0.01).
Mean retinal nerve fiber layer (RNFL) was 100.38 µm +/- 13.9 in patients with MS and 109.65 µm +/- 6.2 in control group (p <0.01). Mean RNFL was 95.76 µm +/- 13.7 in patients with MS and optic neuritis and 102.66 µm +/- 13.09 in patients with MS without optic neuritis (p=0.01). In patients with MS and unilateral optic neuritis, mean RNFL was 102.08+/-9.93 in the affected eye and 102.75 +/- 14.7 in the fellow eye (p=0.45). Mean RNFL was significantly lower in eyes without optic neuritis than in control group (102.66 µm +/- 13.09 vs 109.65 µm +/- 6.2; p <0.01).

Conclusions : SD-OCT is a quick, non-invasive tool to detect subclinical changes in RNFL and macular thickness in patients with MS. Further multicenter studies are needed to assess the usefulness of SD-OCT in monitoring disease progression.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×