June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Changes in relative position of choroidal versus retinal vessels in preterm infants
Author Affiliations & Notes
  • Sang Jin Kim
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
  • J. Peter Campbell
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Susan Ostmo
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Karyn Elizabeth Jonas
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
  • Robison Vernon Paul Chan
    Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, United States
  • Michael F Chiang
    Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Sang Jin Kim, None; J. Peter Campbell, None; Susan Ostmo, None; Karyn Jonas, None; Robison Chan, Visunex Medical Systems (Fremont, CA) (C); Michael Chiang, Clarity Medical Systems (Pleasanton, CA) (S), Novartis (C)
  • Footnotes
    Support  This study was supported by grant R01EY19474, R21EY22387 and P30EY10572 from the National Institutes of Health (Bethesda, MD), by grant 1622679 from the National Science Foundation (Arlington, VA), and by unrestricted departmental funding from Research to Prevent Blindness (New York, NY).
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 5528. doi:
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    • Get Citation

      Sang Jin Kim, J. Peter Campbell, Susan Ostmo, Karyn Elizabeth Jonas, Robison Vernon Paul Chan, Michael F Chiang; Changes in relative position of choroidal versus retinal vessels in preterm infants. Invest. Ophthalmol. Vis. Sci. 2017;58(8):5528.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Little is known about choroidal vascular development in preterm infants. We have observed a novel finding that the relative positions of choroidal and retinal vessels change over time in preterm infants (Figure). The purpose of this study is to describe and analyze the frequency of this finding, and to identify factors associated with this finding using quantitative analysis.

Methods : Consecutive eyes with wide-angle retinal images (RetCam; Natus, Pleasanton, CA) with quality sufficient to enable visualization of choroidal and retinal vessels were analyzed as part of a prospective retinopathy of prematurity (ROP) cohort study. Retinal images captured during routine ROP screening from two sessions 5 to 7 weeks apart were included in this study. For the quantitative analysis, the distance of a characteristic landmark of choroidal vessels (e.g. vascular branch point) between the two sessions were measured. Univariate and multivariate analyses were performed to identify factors associated with the amount of change in relative vascular position.

Results : A total of 37 eyes from 37 preterm infants with mean gestational age (GA) of 26.22 ± 1.49 weeks were analyzed. Changes in relative position of choroidal versus retinal vessels were detected in all 37 eyes. The mean time interval between the two sessions was 6.02 ± 0.61 weeks, and mean postmenstrual age (PMA) at the first session was 32.6 ± 1.43 weeks. The mean difference in choroidal vs. retinal vascular position between the two sessions was 0.55 ± 0.16 mm. Univariate analysis revealed that eyes with type 1 ROP (n=13) showed significantly less movement than eyes with non-type 1 or no ROP (0.46 ± 0.16 vs. 0.60 ± 0.14 mm, P=0.016). PMA at the first time point showed a negative correlation with the distance (R=-0.4832, P=0.0025). Multiple regression analysis revealed that type 1 ROP and PMA at the first time point were significantly associated with less movement of retinal compared to choroidal vessels (P=0.035 and 0.004, respectively).

Conclusions : Choroidal vessels expand outward with respect to retinal vessels in preterm infants, which may imply relatively faster peripheral growth of choroid vs. retinal vessels. Eyes with type 1 ROP showed less difference in growth, which may represent compromised development of choroidal vasculature in eyes with severe ROP. In addition, choroidal growth rate in preterm infants appears to slow over time after birth.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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