June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
PATIENT-SPECIFIC VIRTUAL SIMULATOR OF TISSUE PERFUSION IN THE LAMINA CRIBROSA
Author Affiliations & Notes
  • Lorenzo Sala
    IRMA, Université de Strasbourg, Strasbourg, France
  • Christophe Prud'homme
    Université de Strasbourg, CNRS, IRMA UMR 7501, Strasbourg, France
  • Daniele Prada
    Department of Mathematical Sciences, IUPUI, Indianapolis, Indiana, United States
  • Fabrizia Salerni
    Departiment of Physics and Earth Science, University of Parma, Parma, Italy
  • Christophe Trophime
    LNCMI, Université Grenoble Alpes, Grenoble, France
  • Vincent Chabannes
    IRMA, Université de Strasbourg, Strasbourg, France
  • Marcela Szopos
    Université de Strasbourg, CNRS, IRMA UMR 7501, Strasbourg, France
  • Rodolfo Repetto
    DICCA, University of Genova, Genova, Italy
  • Silvia Bertoluzza
    CNR - IMATI, Pavia, Italy
  • Riccardo Sacco
    Politecnico di Milano, Milano, Italy
  • Alon Harris
    Eugene and Marilyn Glick Eye Institute and Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Giovanna Guidoboni
    LabEx IRMIA, Strasbourg, France
  • Footnotes
    Commercial Relationships   Lorenzo Sala, None; Christophe Prud'homme, None; Daniele Prada, None; Fabrizia Salerni, None; Christophe Trophime, None; Vincent Chabannes, None; Marcela Szopos, None; Rodolfo Repetto, None; Silvia Bertoluzza, None; Riccardo Sacco, None; Alon Harris, AdOM (C), AdOM (I), Biolight (C), Indiana University Research and Technology Corporation (P), Isarna Therapeutics (C), Nano Retina (C), Nano Retina (I), Ono Pharmaceuticals (C), Oxymap (I), ScienceBased Health (C), Stemnion (C); Giovanna Guidoboni, Indiana University Research and Technology Corporation (P)
  • Footnotes
    Support  This work has been partially supported by the Ministère de l'Enseignement supérieur et de la Recherche (France), NSF DMS-1224195, a grant from Research to Prevent Blindness (RPB, NY, USA), the Chair Gutenberg funds of the Cercle Gutenberg (France) and the Labex IRMIA (University of Strasbourg, France)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 727. doi:
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      Lorenzo Sala, Christophe Prud'homme, Daniele Prada, Fabrizia Salerni, Christophe Trophime, Vincent Chabannes, Marcela Szopos, Rodolfo Repetto, Silvia Bertoluzza, Riccardo Sacco, Alon Harris, Giovanna Guidoboni; PATIENT-SPECIFIC VIRTUAL SIMULATOR OF TISSUE PERFUSION IN THE LAMINA CRIBROSA. Invest. Ophthalmol. Vis. Sci. 2017;58(8):727.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Improper perfusion of the lamina cribrosa (LC) may lead to severe alterations of the visual function.
LC perfusion parameters are difficult to estimate with non-invasive measurements and are affected by many factors that vary among individuals and cannot be easily isolated. Here we utilize a mathematical virtual simulator (MVS) to address these challenges.

Methods : The MVS combines i) a three-dimensional porous-media model for LC perfusion with ii) a circuit-based model for blood flow in the retrobulbar and ocular posterior segments (Fig. 1).
Systems i) and ii) are solved using advanced computational and visualization methods (Feel++).
Simulation inputs may include some patient-specific factors that can be measured non-invasively, e.g. systolic blood pressure (SBP), diastolic blood pressure (DBP), intraocular pressure (IOP) and ocular geometry.

Results : Fig. 2a shows the MVS visualization of ocular geometry.
MVS simulated LC perfusion velocities at time t = 2.4 s (green line) are shown for IOP = 15 mmHg and SBP/DBP = 100/70 mmHg (Fig. 2b), SBP/DBP = 120/80 mmHg (Fig. 2c), SBP/DBP = 140/90 mmHg (Fig. 2d).
Increasing SBP and DBP leads to higher LC perfusion velocities, especially near the nasal area.
MVS also simulates blood velocities in the central retinal artery and vein (CRA and CRV), as shown in Figs. 2e and 2f, respectively, which are similar to those obtained via direct Imaging modalities.

Conclusions : MVS may serve as an instrument to illustrate and estimate LC perfusion parameters and predict their spatial variability, thereby providing new means to address the increasing demand of information on parts of the eye that are not-easily accessible with standard investigation instruments.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Figure 1: MVS multiscale scheme

Figure 1: MVS multiscale scheme

 

Figure 2: MVS perfusion simulations

Figure 2: MVS perfusion simulations

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