June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Visualization of depth-localized birefringence of pterygium using polarization sensitive optical coherence tomography
Author Affiliations & Notes
  • Sujin Hoshi
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Deepa Kasaragod
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • Yuta Ueno
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Akari Fujita
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Shinichi Fukuda
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Japan
  • Tetsuro Oshika
    Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Footnotes
    Commercial Relationships   Sujin Hoshi, None; Deepa Kasaragod, Nidek (F), Tomey Corp. (F), TOPCON (F); Yuta Ueno, None; Akari Fujita, None; Shinichi Fukuda, None; Yoshiaki Yasuno, Nidek (F), Tomey Corp. (F), TOPCON (F); Tetsuro Oshika, Tomey Corp. (F), TOPCON (F)
  • Footnotes
    Support  JSPS KAKENHI 15K13371 ; MEXT Program for Building Innovation Ecosystem
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1285. doi:
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    • Get Citation

      Sujin Hoshi, Deepa Kasaragod, Yuta Ueno, Akari Fujita, Shinichi Fukuda, Yoshiaki Yasuno, Tetsuro Oshika; Visualization of depth-localized birefringence of pterygium using polarization sensitive optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1285.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Pterygium is abnormal growth of fibroblasts and degenerated collagen beneath the conjunctiva that penetrates to the corneal surface. Recently, polarization sensitive optical coherence tomography (PS-OCT) has been utilized to visualize birefringence of biological fibrous tissues in the eye. This study aims to visualize and evaluate depth-localized birefringence property of pterygium using PS-OCT.

Methods : 15 eyes of 13 subjects with primary pterygium were imaged using a custom-built PS-OCT. Volumetric scanning was performed to cover 12 mm x 12 mm transversal area. Depth-localized birefringence was subsequently derived from cumulative phase retardation through local Jones matrix analysis. Histological analysis was performed for the cases that had undergone pterygium surgery.

Results : Elevation of depth-localized birefringence of the pterygium was observed in all cases. Figure shows an example of slit-lamp photography (a) and an en face birefringence image (b) of a pterygium case. With en face birefringence image, radial high birefringence band pattern (green) towards the center of the cornea was observed in 11 cases (b). Histological analysis revealed degeneration of collagen fibers matching with the band-shaped high birefringence area of PS-OCT image.

Conclusions : The depth-localized birefringence images clearly visualized birefringence domains of pterygium. Degeneration of collagen fibers and fibrosis in pterygium might be able to noninvasively visualized using PS-OCT.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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