June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Risk factors of Recurrence of Macular Edema Associated with Branch Retinal Vein Occlusion after Intravitreal Bevacizumab Injection
Author Affiliations & Notes
  • Seong-Woo Kim
    Ophthalmology, Korea University, College of Medicine, Ansan, Korea (the Republic of)
  • Jun Ho Yoo
    Ophthalmology, Korea University, College of Medicine, Ansan, Korea (the Republic of)
  • Jaemoon Ahn
    Ophthalmology, Korea University, College of Medicine, Ansan, Korea (the Republic of)
  • jiyun Han
    Ophthalmology, Korea University, College of Medicine, Ansan, Korea (the Republic of)
  • Jaeryung Oh
    Ophthalmology, Korea University, College of Medicine, Ansan, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Seong-Woo Kim, None; Jun Ho Yoo, None; Jaemoon Ahn, None; jiyun Han, None; Jaeryung Oh, None
  • Footnotes
    Support  This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education (NRF-2016R1D1A1A02937018)
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1552. doi:
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      Seong-Woo Kim, Jun Ho Yoo, Jaemoon Ahn, jiyun Han, Jaeryung Oh; Risk factors of Recurrence of Macular Edema Associated with Branch Retinal Vein Occlusion after Intravitreal Bevacizumab Injection. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1552.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify risk factors of recurrence of macular edema in branch retinal vein occlusion (BRVO) after intravitreal bevacizumab (IVB) injection.

Methods : The records of 63 patients who underwent IVB injection for macular edema secondary to BRVO with at least 6 months of follow-up were reviewed. Patients were evaluated at baseline with fluorescein angiography (FA), optical coherence tomography (OCT), and ultra-wide-field fundus photography (WFP). During follow-up, OCT and WFP were repeated. The area of retinal hemorrhage, central retinal thickness (CRT), area (mm2) of abnormal capillary non-perfusion within the 1-mm (NPA1) and 3-mm (NPA3) zones of the ETDRS circle, foveal capillary filling time, degree (°) of foveal capillary network destruction, and FA pattern were analyzed.

Results : The records of 63 patients who underwent IVB injection for macular edema secondary to BRVO with at least 6 months of follow-up were reviewed. Patients were evaluated at baseline with fluorescein angiography (FA), optical coherence tomography (OCT), and ultra-wide-field fundus photography (WFP). During follow-up, OCT and WFP were repeated. The area of retinal hemorrhage, central retinal thickness (CRT), area (mm2) of abnormal capillary non-perfusion within the 1-mm (NPA1) and 3-mm (NPA3) zones of the ETDRS circle, foveal capillary filling time, degree (°) of foveal capillary network destruction, and FA pattern were analyzed.

Conclusions : In BRVO patients with non-perfusion of more than half of the 1-mm zone of the ETDRS circle or whose initial CRT is more than 570 µm, a high degree of suspicion of macular edema recurrence within 6 months of IVB injection is warranted.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

Measurement of the extent of foveal capillary network destruction and the capillary non-perfusion area

Measurement of the extent of foveal capillary network destruction and the capillary non-perfusion area

 

Receiver operating characteristic curve for the area of capillary non-perfusion within the ETDRS circle 1-mm zone and the initial central retinal thickness, used as a predictor of macular edema recurrence after IVB injection for branch retinal vein occlusion associated with macular edema.

Receiver operating characteristic curve for the area of capillary non-perfusion within the ETDRS circle 1-mm zone and the initial central retinal thickness, used as a predictor of macular edema recurrence after IVB injection for branch retinal vein occlusion associated with macular edema.

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