June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
Swept source optical coherence tomography angiography in choroidal melanoma
Author Affiliations & Notes
  • Marco Pellegrini
    Eye Clinic, Department of Biomedical and Clinical Sciences “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Italy, Milan, Italy
  • Federico Corvi
    Eye Clinic, Department of Biomedical and Clinical Sciences “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Italy, Milan, Italy
  • Vittoria Ravera
    Eye Clinic, Department of Biomedical and Clinical Sciences “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Italy, Milan, Italy
  • Giovanni Staurenghi
    Eye Clinic, Department of Biomedical and Clinical Sciences “Luigi Sacco”, Luigi Sacco Hospital, University of Milan, Italy, Milan, Italy
  • Footnotes
    Commercial Relationships   Marco Pellegrini, Optovue Inc. (R); Federico Corvi, None; Vittoria Ravera, None; Giovanni Staurenghi, Alcon (C), Alcon (R), Allergan (C), Bayer (C), Bayer (R), Boehringer Ingelheim (C), Genentech (C), Heidelberg Engineering (C), Heidelberg Engineering (R), Novartis (F), Novartis (C), Novartis (R), Ocular Instruments (P), Optos (C), Optovue Inc. (F), Roche (C), Zeiss (F), Zeiss (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1694. doi:
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    • Get Citation

      Marco Pellegrini, Federico Corvi, Vittoria Ravera, Giovanni Staurenghi; Swept source optical coherence tomography angiography in choroidal melanoma. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1694.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the imaging features of choroidal melanoma using swept source optical coherence tomography angiography (OCT-A) and evaluate its ability to display tumor intrinsic vasculature.

Methods : Patients with choroidal melanoma underwent a complete ophthalmic evaluation, including best corrected visual acuity, color fundus photography, B-scan ultrasound, fluorescein angiography (FA), indocyanine green angiography (ICGA) and swept source OCT-A with Zeiss prototype (PLEX Elite, Swept-Source OCT model 9000, Carl Zeiss Meditec, Inc, Dublin, CA).

Results : Twenty-two eyes of 22 consecutive patients with choroidal melanoma were included in the study; 11 cases (50%) were treatment naïve. Three lesions (14%) were located at the macula, 14 (63%) between the macula and equator and 5 (23%) between the equator and the ora serrata. The mean tumor base and thickness were respectively 10.3 mm (range 5-15 mm) and 4.5 mm (range 1.5-8.9 mm). Seventeen lesions (77%) were dome shaped whereas 5 (23%) showed a mushroom configuration. Thirteen lesions (59%) were pigmented, 5 (23%) partially pigmented and 4 (18%) amelanotic. An exudative retinal detachment was detected in 13 eyes (59%). FA and ICGA disclosed intrinsic microvasculature of the tumor respectively in 4 (20%) and 22 (100%) cases whereas OCT-A detected microvasculature of choroidal melanoma in all cases. Specifically, intrinsic vasculature could be recognized in 14 eyes (64%) using the automated choroid segmentation, 16 eyes (73%) using the automated whole eye segmentation and in 22 eyes (100%) with fine manual adjustments of segmentation lines.

Conclusions : Swept source OCT-A represents a valid imaging technique in evaluating patients affected by choroidal melanomas. In our series OCT-A disclosed the intrinsic microvasculature of the tumor in all cases despite their size and position.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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