June 2017
Volume 58, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2017
THE rs4712527 POLYMORPHISM IN THE CDKAL1 GENE, AS A PROTECTIVE PREDICTOR OF PROLIFERATIVE DIABETIC RETINOPATHY DEVELOPMENT IN TYPE 2 DIABETIC PATIENTS.
Author Affiliations & Notes
  • Jose D Luna Pinto
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Pablo Yang
    Cátedra de Biotecnología,, Facultad de Ciencias Químicas, Universidad Católica de Córdoba. Unidad Asociada al CONICET: Área de Cs. Agrarias, Ingeniería, Cs. Biológicas., Cordoba, Cordoba, Argentina
  • Aylen Sein
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Laura Gramajo
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Emilia Aucar
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Gabriel Marquez
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Claudio P Juarez
    Ophthalmology, Ctr Privado de Ojos Romagosa-Fndtn VER, Mendiolaza, Argentina
  • Dante M Beltramo
    Centro de Excelencia en Productos y Procesos (CEPROCOR) Pabellón CEPROCOR, SantaMaría de Punilla, , Cordoba, Cordoba, Argentina
  • Nestor W Soria
    Cátedra de Biotecnología,, Facultad de Ciencias Químicas, Universidad Católica de Córdoba. Unidad Asociada al CONICET: Área de Cs. Agrarias, Ingeniería, Cs. Biológicas., Cordoba, Cordoba, Argentina
  • Footnotes
    Commercial Relationships   Jose Luna Pinto, None; Pablo Yang, None; Aylen Sein, None; Laura Gramajo, None; Emilia Aucar, None; Gabriel Marquez, None; Claudio Juarez, None; Dante Beltramo, None; Nestor Soria, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2017, Vol.58, 1848. doi:
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      Jose D Luna Pinto, Pablo Yang, Aylen Sein, Laura Gramajo, Emilia Aucar, Gabriel Marquez, Claudio P Juarez, Dante M Beltramo, Nestor W Soria; THE rs4712527 POLYMORPHISM IN THE CDKAL1 GENE, AS A PROTECTIVE PREDICTOR OF PROLIFERATIVE DIABETIC RETINOPATHY DEVELOPMENT IN TYPE 2 DIABETIC PATIENTS.. Invest. Ophthalmol. Vis. Sci. 2017;58(8):1848.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate whether the presence of seven polymorphisms in six candidate genes is associated with proliferative diabetic retinopathy (PDR) in a cohort of Argentinean patients with type 2 diabetes mellitus (DM2)

Methods : A total of 231 patients (126 patients with PDR and 105 patients with DM but without PDR) who were not diagnosed with DM2 and assisted at the Romagosa Eye Clinic were studied. Anthropometric and ophthalmologic parameters were evaluated. Blood glucose levels, HbA1c and lipid profile were measured. It was recorded whether they were smokers, type of pharmacological treatment received, blood pressure, years of disease duration and presence / absence of macular edema. The presence of the polymorphisms MTHFR (rs1801133), bFGF (553 T> A), CDKAL1 (rs4712527), VEGF (rs699947, rs35569394), TCF7L2 (rs7903146) and ECA (rs4646994) were analyzed by the PCR-RFLP technique

Results : The presence of the rs4712527 polymorphism of the CDKAL1 gene confers a lower risk of developing proliferative diabetic retinopathy (OR = 0.34, 95% CI = 0.13-0.87, P = 0.022). The polymorphisms MTHFR (rs1801133), bFGF (553 T> A), VEGF (rs699947, rs35569394), TCF7L2 (rs7903146) and ECA (rs4646994) showed no significant differences.

Conclusions : The present study shows for the first time the association between the presence of the polymorphism G of rs4712527 in the CDKAL1 gene as a protective factor in the development of proliferative diabetic retinopathy in Argentine patients with DM2. The same association with the other polymorphisms studied has not been found.

This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.

 

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